LAG3_HUMAN » Lymphocyte activation gene 3 protein

LAG3_HUMAN » Lymphocyte activation gene 3 protein
Magnify LAG3_HUMAN » Lymphocyte activation gene 3 proteinEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LAG3_HUMAN » Lymphocyte activation gene 3 protein » LAG-3; Protein FDC;
Hydrophobic Thickness 34.4 ± 2.6 Å
Tilt Angle 40 ± 0°
ΔGtransfer -28.2 kcal/mol
ΔGfold -22.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 444-472 (444-479)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 169-259, Immunoglobulin domain

AA: 262-353, Immunoglobulin domain

UniProt annotation for LAG3_HUMAN » Lymphocyte activation gene 3 protein
FUNCTION: Involved in lymphocyte activation. Binds to HLA class-II antigens.

TISSUE SPECIFICITY: On cell surface of activated NK and T- lymphocytes.

UniProt features for LAG3_HUMAN » Lymphocyte activation gene 3 protein
SIGNAL 1 28
CHAIN 29 525 Lymphocyte activation gene 3 protein.
DOMAIN 37 167 Ig-like V-type.
DOMAIN 168 252 Ig-like C2-type 1.
DOMAIN 265 343 Ig-like C2-type 2.
DOMAIN 348 419 Ig-like C2-type 3.
REGION 501 524 12 X 2 AA tandem repeats of E-X.
DISULFID 44 160 Potential.
DISULFID 189 241 Potential.
DISULFID 282 333 Potential.
DISULFID 369 412 Potential.
Amino Acid Sequence for LAG3_HUMAN » Lymphocyte activation gene 3 protein
MWEAQFLGLL FLQPLWVAPV KPLQPGAEVP VVWAQEGAPA QLPCSPTIPL QDLSLLRRAG VTWQHQPDSG PPAAAPGHPL APGPHPAAPS SWGPRPRRYT VLSVGPGGLR SGRLPLQPRV QLDERGRQRG DFSLWLRPAR RADAGEYRAA VHLRDRALSC RLRLRLGQAS MTASPPGSLR ASDWVILNCS FSRPDRPASV HWFRNRGQGR VPVRESPHHH LAESFLFLPQ VSPMDSGPWG CILTYRDGFN VSIMYNLTVL GLEPPTPLTV YAGAGSRVGL PCRLPAGVGT RSFLTAKWTP PGGGPDLLVT GDNGDFTLRL EDVSQAQAGT YTCHIHLQEQ QLNATVTLAI ITVTPKSFGS PGSLGKLLCE VTPVSGQERF VWSSLDTPSQ RSFSGPWLEA QEAQLLSQPW QCQLYQGERL LGAAVYFTEL SSPGAQRSGR APGALPAGHL LLFLILGVLS LLLLVTGAFG FHLWRRQWRP RRFSALEQGI HPPQAQSKIE ELEQEPEPEP EPEPEPEPEP EPEQL