KREM2_HUMAN » Kremen protein 2

KREM2_HUMAN » Kremen protein 2
Magnify KREM2_HUMAN » Kremen protein 2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KREM2_HUMAN » Kremen protein 2 » Dickkopf receptor 2;Kringle domain-containing transmembrane protein 2;Kringle-containing protein marking the eye and the nose;
Hydrophobic Thickness 33.0 ± 3.3 Å
Tilt Angle 4 ± 2°
ΔGtransfer -20.4 kcal/mol
ΔGfold -13.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 367-388 (367-388)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 36-119, PDBID: 2KNF, Subunit A, Seq Identity:41%, Kringle domain

AA: 124-205, WSC domain

AA: 219-323, PDBID: 3KQ4, Subunit B, Seq Identity:33%, CUB domain

UniProt annotation for KREM2_HUMAN » Kremen protein 2
FUNCTION: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane (By similarity).

SUBUNIT: Interacts with ERLEC1.

DOMAIN: Binding to ERLEC1 is mediated by the oligosaccharides linked to the kringle domain.

UniProt features for KREM2_HUMAN » Kremen protein 2
SIGNAL 1 25 Potential.
CHAIN 26 462 Kremen protein 2.
DOMAIN 35 119 Kringle.
DOMAIN 121 215 WSC.
DOMAIN 219 326 CUB.
DISULFID 36 119 By similarity.
DISULFID 60 100 By similarity.
DISULFID 89 114 By similarity.
DISULFID 219 245 By similarity.
Amino Acid Sequence for KREM2_HUMAN » Kremen protein 2
MGTQALQGFL FLLFLPLLQP RGASAGSLHS PGLSECFQVN GADYRGHQNR TGPRGAGRPC LFWDQTQQHS YSSASDPHGR WGLGAHNFCR NPDGDVQPWC YVAETEEGIY WRYCDIPSCH MPGYLGCFVD SGAPPALSGP SGTSTKLTVQ VCLRFCRMKG YQLAGVEAGY ACFCGSESDL ARGRLAPATD CDQICFGHPG QLCGGDGRLG VYEVSVGSCQ GNWTAPQGVI YSPDFPDEYG PDRNCSWALG PPGAALELTF RLFELADPRD RLELRDAASG SLLRAFDGAR PPPSGPLRLG TAALLLTFRS DARGHAQGFA LTYRGLQDAA EDPEAPEGSA QTPAAPLDGA NVSCSPRPGA PPAAIGARVF STVTAVSVLL LLLLGLLRPL RRRSCLLAPG KGPPALGASR GPRRSWAVWY QQPRGVALPC SPGDPQAEGS AAGYRPLSAS SQSSLRSLIS AL