KREM1_HUMAN » Kremen protein 1

KREM1_HUMAN » Kremen protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KREM1_HUMAN » Kremen protein 1 » Dickkopf receptor;Kringle domain-containing transmembrane protein 1;Kringle-containing protein marking the eye and the nose;
Hydrophobic Thickness 34.8 ± 2.0 Å
Tilt Angle 14 ± 9°
ΔGtransfer -28.0 kcal/mol
ΔGfold -19.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 391-416 (391-421)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 32-114, PDBID: 1PK2, Subunit A, Seq Identity:40%, Kringle domain

AA: 119-200, WSC domain

AA: 214-318, PDBID: 2WNO, Subunit A, Seq Identity:36%, CUB domain

UniProt annotation for KREM1_HUMAN » Kremen protein 1
FUNCTION: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity).
UniProt features for KREM1_HUMAN » Kremen protein 1
SIGNAL 1 19 Potential.
CHAIN 20 473 Kremen protein 1.
DOMAIN 31 114 Kringle.
DOMAIN 116 210 WSC.
DOMAIN 214 321 CUB.
DISULFID 32 114 By similarity.
DISULFID 55 95 By similarity.
DISULFID 84 109 By similarity.
DISULFID 214 240 By similarity.
Amino Acid Sequence for KREM1_HUMAN » Kremen protein 1
MAPPAARLAL LSAAALTLAA RPAPSPGLGP ECFTANGADY RGTQNWTALQ GGKPCLFWNE TFQHPYNTLK YPNGEGGLGE HNYCRNPDGD VSPWCYVAEH EDGVYWKYCE IPACQMPGNL GCYKDHGNPP PLTGTSKTSN KLTIQTCISF CRSQRFKFAG MESGYACFCG NNPDYWKYGE AASTECNSVC FGDHTQPCGG DGRIILFDTL VGACGGNYSA MSSVVYSPDF PDTYATGRVC YWTIRVPGAS HIHFSFPLFD IRDSADMVEL LDGYTHRVLA RFHGRSRPPL SFNVSLDFVI LYFFSDRINQ AQGFAVLYQA VKEELPQERP AVNQTVAEVI TEQANLSVSA ARSSKVLYVI TTSPSHPPQT VPGSNSWAPP MGAGSHRVEG WTVYGLATLL ILTVTAIVAK ILLHVTFKSH RVPASGDLRD CHQPGTSGEI WSIFYKPSTS ISIFKKKLKG QSQQDDRNPL VSD