KLRG1_HUMAN » Killer cell lectin-like receptor subfamily G member 1

KLRG1_HUMAN » Killer cell lectin-like receptor subfamily G member 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KLRG1_HUMAN » Killer cell lectin-like receptor subfamily G member 1 » C-type lectin domain family 15 member A;ITIM-containing receptor MAFA-L;MAFA-like receptor;Mast cell function-associated antigen;
Hydrophobic Thickness 37.6 ± 3.0 Å
Tilt Angle 3 ± 1°
ΔGtransfer -41.2 kcal/mol
ΔGfold -18.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 35-59 (33-64)
Pathways

Immune System (Reactome)

PDB 3ff7 (C/D=75-186)
OPM none
Complexes

KLRG1:CADH1_HUMAN

KLRG1:KLRG1_MOUSE

Interactions

CADH1, Complex: CADH1:KLRG1, PDBID: 3ff7

KLRG1, Complex: Homodimer of killer cell lectin-like receptor subfamily G member 1, PDBID: 3FF9

SYNE4, Complex: SYNE4:KLRG1

Domains

AA: 92-186, PDBID: 3FF7, Subunit C, Seq Identity:100%, Lectin C-type domain

UniProt annotation for KLRG1_HUMAN » Killer cell lectin-like receptor subfamily G member 1
FUNCTION: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.

SUBUNIT: Forms a monomer and homodimer; disulfide-linked. Interacts (via ITIM motif) with PTPN11 and INPP5D.

TISSUE SPECIFICITY: Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells.

INDUCTION: By pathogens and viruses infections.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases PTPN11 and INPP5D (By similarity).

UniProt features for KLRG1_HUMAN » Killer cell lectin-like receptor subfamily G member 1
CHAIN 1 195 Killer cell lectin-like receptor subfamily G member 1.
DOMAIN 82 185 C-type lectin.
MOTIF 5 10 ITIM motif.
DISULFID 75 86
DISULFID 103 184
DISULFID 163 176
Amino Acid Sequence for KLRG1_HUMAN » Killer cell lectin-like receptor subfamily G member 1
MTDSVIYSML ELPTATQAQN DYGPQQKSSS SRPSCSCLVA IALGLLTAVL LSVLLYQWIL CQGSNYSTCA SCPSCPDRWM KYGNHCYYFS VEEKDWNSSL EFCLARDSHL LVITDNQEMS LLQVFLSEAF CWIGLRNNSG WRWEDGSPLN FSRISSNSFV QTCGAINKNG LQASSCEVPL HWVCKKCPFA DQALF