KLRF2_HUMAN » Killer cell lectin-like receptor subfamily F member 2

KLRF2_HUMAN » Killer cell lectin-like receptor subfamily F member 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KLRF2_HUMAN » Killer cell lectin-like receptor subfamily F member 2 » Lectin-like receptor F2; Activating coreceptor NKp65;
Hydrophobic Thickness 30.8 ± 2.2 Å
Tilt Angle 0 ± 2°
ΔGtransfer -39.1 kcal/mol
ΔGfold -23.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 29-57 (29-60)
Pathways none
PDB 4iop (B=63-207)
OPM none
Complexes

KLRF2:CLC2A_HUMAN

Interactions

CLC2A, Complex: CLC2A:KLRF2, PDBID: 4IOP, PubMed

Domains

AA: 95-195, PDBID: 4IOP, Subunit B, Seq Identity:100%, Lectin C-type domain

UniProt annotation for KLRF2_HUMAN » Killer cell lectin-like receptor subfamily F member 2
FUNCTION: C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A.

SUBUNIT: Homodimer; non disulfide-linked. Interacts with CLEC2A.

UniProt features for KLRF2_HUMAN » Killer cell lectin-like receptor subfamily F member 2
CHAIN 1 207 Killer cell lectin-like receptor subfamily F member 2.
DOMAIN 85 194 C-type lectin.
DISULFID 106 193 By similarity.
DISULFID 172 185 By similarity.
Amino Acid Sequence for KLRF2_HUMAN » Killer cell lectin-like receptor subfamily F member 2
MENEDGYMTL SFKNRCKSKQ KSKDFSLYPQ YYCLLLIFGC IVILIFIMTG IDLKFWHKKM DFSQNVNVSS LSGHNYLCPN DWLLNEGKCY WFSTSFKTWK ESQRDCTQLQ AHLLVIQNLD ELEFIQNSLK PGHFGWIGLY VTFQGNLWMW IDEHFLVPEL FSVIGPTDDR SCAVITGNWV YSEDCSSTFK GICQRDAILT HNGTSGV