KLRF1_HUMAN » Killer cell lectin-like receptor subfamily F member 1

KLRF1_HUMAN » Killer cell lectin-like receptor subfamily F member 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KLRF1_HUMAN » Killer cell lectin-like receptor subfamily F member 1 » Lectin-like receptor F1; Activating coreceptor NKp80;C-type lectin domain family 5 member C;
Hydrophobic Thickness 32.0 ± 2.2 Å
Tilt Angle 0 ± 2°
ΔGtransfer -37.4 kcal/mol
ΔGfold -11.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 45-70 (43-72)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 132-232, PDBID: 4IOP, Subunit B, Seq Identity:41%, Lectin C-type domain

UniProt annotation for KLRF1_HUMAN » Killer cell lectin-like receptor subfamily F member 1
FUNCTION: Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts.

SUBUNIT: Homodimer.

TISSUE SPECIFICITY: Strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Not expressed in brain, heart, placenta, lung, kidney, skeletal muscle, and pancreas. Within peripheral blood leukocyte and immunocyte cell lines, expression was predominant in NK cells but was also detected in monocytes.

UniProt features for KLRF1_HUMAN » Killer cell lectin-like receptor subfamily F member 1
CHAIN 1 232 Killer cell lectin-like receptor subfamily F member 1.
DOMAIN 121 231 C-type lectin.
DISULFID 143 230 By similarity.
DISULFID 209 222 By similarity.
Amino Acid Sequence for KLRF1_HUMAN » Killer cell lectin-like receptor subfamily F member 1
MQDEERYMTL NVQSKKRSSA QTSQLTFKDY SVTLHWYKIL LGISGTVNGI LTLTLISLIL LVSQGVLLKC QKGSCSNATQ YEDTGDLKVN NGTRRNISNK DLCASRSADQ TVLCQSEWLK YQGKCYWFSN EMKSWSDSYV YCLERKSHLL IIHDQLEMAF IQKNLRQLNY VWIGLNFTSL KMTWTWVDGS PIDSKIFFIK GPAKENSCAA IKESKIFSET CSSVFKWICQ Y