KLRD1_HUMAN » Natural killer cells antigen CD94

KLRD1_HUMAN » Natural killer cells antigen CD94
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KLRD1_HUMAN » Natural killer cells antigen CD94 » KP43;Killer cell lectin-like receptor subfamily D member 1;NK cell receptor;
Hydrophobic Thickness 33.6 ± 3.2 Å
Tilt Angle 24 ± 7°
ΔGtransfer -19.5 kcal/mol
ΔGfold -10.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 7-32 (7-32)
Pathways

Antigen processing and presentation (KEGG)

Graft-versus-host disease (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

PDB 1b6e (52-179), 3bdw (A/C=57-179), 3cdg (E/J=57-179), 3cii (G/I=59-179)
OPM none
Complexes

HLAE:NKG2A:KLRD1:HLAG:B2MG_HUMAN

NKG2A:KLRD1_HUMAN

Interactions

1B07, Complex: 1B07:KLRD1, PubMed

HLAE, Complex: B2MG:HLAE:HLAG:KLRD1:NKG2A, PDBID: 3cdg

HLAG, Complex: B2MG:HLAE:HLAG:KLRD1:NKG2A, PDBID: 3cdg

NKG2A, Complex: B2MG:HLAE:HLAG:KLRD1:NKG2A, PDBID: 3cdg

NKG2C, Complex: NKG2C:TYOBP:KLRD1, PubMed

NKG2E, Complex: KLRD1:NKG2E, PubMed

TYOBP, Complex: KLRD1:TYOBP:NKG2C, PubMed

Domains

AA: 78-176, PDBID: 1B6E, Subunit A, Seq Identity:100%, Lectin C-type domain

UniProt annotation for KLRD1_HUMAN » Natural killer cells antigen CD94
FUNCTION: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

SUBUNIT: Can form disulfide-bonded heterodimer with NKG2 family members.

TISSUE SPECIFICITY: Natural killer cells.

UniProt features for KLRD1_HUMAN » Natural killer cells antigen CD94
CHAIN 1 179 Natural killer cells antigen CD94.
DOMAIN 68 175 C-type lectin.
DISULFID 58 70
DISULFID 59 59 Interchain (with C-116 in NGK2A).
DISULFID 61 72
DISULFID 89 174
DISULFID 152 166
Amino Acid Sequence for KLRD1_HUMAN » Natural killer cells antigen CD94
MAVFKTTLWR LISGTLGIIC LSLMATLGIL LKNSFTKLSI EPAFTPGPNI ELQKDSDCCS CQEKWVGYRC NCYFISSEQK TWNESRHLCA SQKSSLLQLQ NTDELDFMSS SQQFYWIGLS YSEEHTAWLW ENGSALSQYL FPSFETFNTK NCIAYNPNGN ALDESCEDKN RYICKQQLI