|KLRB1_HUMAN » Killer cell lectin-like receptor subfamily B member 1 » C-type lectin domain family 5 member B;HNKR-P1a;NKR-P1A; Natural killer cell surface protein P1A;|
|Hydrophobic Thickness||37.2 ± 2.6 Å|
|Tilt Angle||0 ± 3°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB|
|TM Segments||39-66 (37-72)|
|UniProt annotation for KLRB1_HUMAN » Killer cell lectin-like receptor subfamily B member 1|
|FUNCTION: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1. TISSUE SPECIFICITY: Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype. INDUCTION: By IL12/interleukin-12 in NK cells.|
|UniProt features for KLRB1_HUMAN » Killer cell lectin-like receptor subfamily B member 1|
CHAIN 1 225 Killer cell lectin-like receptor subfamily B member 1. |
DOMAIN 101 211 C-type lectin.
DISULFID 94 105 By similarity.
DISULFID 122 210 By similarity.
DISULFID 189 202 By similarity.
|Amino Acid Sequence for KLRB1_HUMAN » Killer cell lectin-like receptor subfamily B member 1|
|MDQQAIYAEL NLPTDSGPES SSPSSLPRDV CQGSPWHQFA LKLSCAGIIL LVLVVTGLSV SVTSLIQKSS IEKCSVDIQQ SRNKTTERPG LLNCPIYWQQ LREKCLLFSH TVNPWNNSLA DCSTKESSLL LIRDKDELIH TQNLIRDKAI LFWIGLNFSL SEKNWKWING SFLNSNDLEI RGDAKENSCI SISQTSVYSE YCSTEIRWIC QKELTPVRNK VYPDS|