KLRB1_HUMAN » Killer cell lectin-like receptor subfamily B member 1

KLRB1_HUMAN » Killer cell lectin-like receptor subfamily B member 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KLRB1_HUMAN » Killer cell lectin-like receptor subfamily B member 1 » C-type lectin domain family 5 member B;HNKR-P1a;NKR-P1A; Natural killer cell surface protein P1A;
Hydrophobic Thickness 37.2 ± 2.6 Å
Tilt Angle 0 ± 3°
ΔGtransfer -40.4 kcal/mol
ΔGfold -17.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 39-66 (37-72)
Pathways

Malaria (KEGG)

PDB none
OPM none
Complexes none
Interactions

CLC2D, Complex: CLC2D:KLRB1, PubMed

Domains

AA: 111-212, PDBID: 2MTI, Subunit A, Seq Identity:49%, Lectin C-type domain

UniProt annotation for KLRB1_HUMAN » Killer cell lectin-like receptor subfamily B member 1
FUNCTION: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

SUBUNIT: Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1.

TISSUE SPECIFICITY: Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.

INDUCTION: By IL12/interleukin-12 in NK cells.

UniProt features for KLRB1_HUMAN » Killer cell lectin-like receptor subfamily B member 1
CHAIN 1 225 Killer cell lectin-like receptor subfamily B member 1.
DOMAIN 101 211 C-type lectin.
DISULFID 94 105 By similarity.
DISULFID 122 210 By similarity.
DISULFID 189 202 By similarity.
Amino Acid Sequence for KLRB1_HUMAN » Killer cell lectin-like receptor subfamily B member 1
MDQQAIYAEL NLPTDSGPES SSPSSLPRDV CQGSPWHQFA LKLSCAGIIL LVLVVTGLSV SVTSLIQKSS IEKCSVDIQQ SRNKTTERPG LLNCPIYWQQ LREKCLLFSH TVNPWNNSLA DCSTKESSLL LIRDKDELIH TQNLIRDKAI LFWIGLNFSL SEKNWKWING SFLNSNDLEI RGDAKENSCI SISQTSVYSE YCSTEIRWIC QKELTPVRNK VYPDS