KIRR2_HUMAN » Kin of IRRE-like protein 2

KIRR2_HUMAN » Kin of IRRE-like protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KIRR2_HUMAN » Kin of IRRE-like protein 2 » Kin of irregular chiasm-like protein 2;Nephrin-like protein 3;
Hydrophobic Thickness 30.8 ± 1.6 Å
Tilt Angle 1 ± 0°
ΔGtransfer -36.6 kcal/mol
ΔGfold -15.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 507-534 (507-539)
Pathways

Cell-Cell communication (Reactome)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 24-121, PDBID: 4OF8, Subunit C, Seq Identity:39%, Immunoglobulin I-set domain

AA: 127-214, PDBID: 4OFD, Subunit B, Seq Identity:40%, CD80-like C2-set immunoglobulin domain

AA: 312-378, PDBID: 2OM5, Subunit A, Seq Identity:41%, Immunoglobulin domain

UniProt annotation for KIRR2_HUMAN » Kin of IRRE-like protein 2
SUBUNIT: Interacts with NPHS2/podocin (via the C-terminus). Interacts with NPHS1 (via the Ig-like domains) (By similarity).

TISSUE SPECIFICITY: Highly expressed in beta-cells of the pancreatic islets.

UniProt features for KIRR2_HUMAN » Kin of IRRE-like protein 2
SIGNAL 1 20
CHAIN 21 708 Kin of IRRE-like protein 2.
DOMAIN 24 118 Ig-like C2-type 1.
DOMAIN 123 222 Ig-like C2-type 2.
DOMAIN 227 307 Ig-like C2-type 3.
DOMAIN 312 394 Ig-like C2-type 4.
DOMAIN 398 501 Ig-like C2-type 5.
MOTIF 149 151 Cell attachment site (Potential).
DISULFID 45 103 By similarity.
DISULFID 146 204 By similarity.
DISULFID 248 291 By similarity.
DISULFID 333 375 By similarity.
DISULFID 419 485 By similarity.
Amino Acid Sequence for KIRR2_HUMAN » Kin of IRRE-like protein 2
MLRMRVPALL VLLFCFRGRA GPSPHFLQQP EDLVVLLGEE ARLPCALGAY WGLVQWTKSG LALGGQRDLP GWSRYWISGN AANGQHDLHI RPVELEDEAS YECQATQAGL RSRPAQLHVL VPPEAPQVLG GPSVSLVAGV PANLTCRSRG DARPTPELLW FRDGVLLDGA TFHQTLLKEG TPGSVESTLT LTPFSHDDGA TFVCRARSQA LPTGRDTAIT LSLQYPPEVT LSASPHTVQE GEKVIFLCQA TAQPPVTGYR WAKGGSPVLG ARGPRLEVVA DASFLTEPVS CEVSNAVGSA NRSTALDVLF GPILQAKPEP VSVDVGEDAS FSCAWRGNPL PRVTWTRRGG AQVLGSGATL RLPSVGPEDA GDYVCRAEAG LSGLRGGAAE ARLTVNAPPV VTALHSAPAF LRGPARLQCL VFASPAPDAV VWSWDEGFLE AGSQGRFLVE TFPAPESRGG LGPGLISVLH ISGTQESDFS RSFNCSARNR LGEGGAQASL GRRDLLPTVR IVAGVAAATT TLLMVITGVA LCCWRHSKAS ASFSEQKNLM RIPGSSDGSS SRGPEEEETG SREDRGPIVH TDHSDLVLEE EGTLETKDPT NGYYKVRGVS VSLSLGEAPG GGLFLPPPSP LGPPGTPTFY DFNPHLGMVP PCRLYRARAG YLTTPHPRAF TSYIKPTSFG PPDLAPGTPP FPYAAFPTPS HPRLQTHV