KIRR1_HUMAN » Kin of IRRE-like protein 1

KIRR1_HUMAN » Kin of IRRE-like protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KIRR1_HUMAN » Kin of IRRE-like protein 1 » Kin of irregular chiasm-like protein 1;Nephrin-like protein 1;
Hydrophobic Thickness 38.0 ± 1.2 Å
Tilt Angle 0 ± 1°
ΔGtransfer -60.4 kcal/mol
ΔGfold -27.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 500-522 (492-525)
Pathways

Cell-Cell communication (Reactome)

PDB none
OPM none
Complexes

KIRR1:KIRR1_MOUSE

Interactions

KIRR1, Complex: Homodimer of kin of IRRE-like protein 1, PDBID: 4OFD

NPHN, Complex: NPHN:KIRR1, PubMed

Domains

AA: 21-118, PDBID: 4OFD, Subunit B, Seq Identity:100%, Immunoglobulin I-set domain

AA: 118-208, PDBID: 4OFD, Subunit B, Seq Identity:94%, CD80-like C2-set immunoglobulin domain

AA: 307-374, PDBID: 1CS6, Subunit A, Seq Identity:42%, Immunoglobulin domain

UniProt annotation for KIRR1_HUMAN » Kin of IRRE-like protein 1
FUNCTION: Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).

SUBUNIT: Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL glycosylation. Homodimer (via the Ig-like domains). Interacts when tyrosine- phosphorylated with GRB2 (By similarity).

TISSUE SPECIFICITY: Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.

UniProt features for KIRR1_HUMAN » Kin of IRRE-like protein 1
SIGNAL 1 16 Potential.
CHAIN 17 757 Kin of IRRE-like protein 1.
DOMAIN 21 115 Ig-like C2-type 1.
DOMAIN 120 216 Ig-like C2-type 2.
DOMAIN 223 299 Ig-like C2-type 3.
DOMAIN 308 387 Ig-like C2-type 4.
DOMAIN 392 488 Ig-like C2-type 5.
MOTIF 405 407 Cell attachment site (Potential).
DISULFID 42 100 By similarity.
DISULFID 143 200 By similarity.
DISULFID 244 287 By similarity.
DISULFID 329 371 By similarity.
DISULFID 413 472 By similarity.
Amino Acid Sequence for KIRR1_HUMAN » Kin of IRRE-like protein 1
MLSLLVWILT LSDTFSQGTQ TRFSQEPADQ TVVAGQRAVL PCVLLNYSGI VQWTKDGLAL GMGQGLKAWP RYRVVGSADA GQYNLEITDA ELSDDASYEC QATEAALRSR RAKLTVLIPP EDTRIDGGPV ILLQAGTPHN LTCRAFNAKP AATIIWFRDG TQQEGAVAST ELLKDGKRET TVSQLLINPT DLDIGRVFTC RSMNEAIPSG KETSIELDVH HPPTVTLSIE PQTVQEGERV VFTCQATANP EILGYRWAKG GFLIEDAHES RYETNVDYSF FTEPVSCEVH NKVGSTNVST LVNVHFAPRI VVDPKPTTTD IGSDVTLTCV WVGNPPLTLT WTKKDSNMVL SNSNQLLLKS VTQADAGTYT CRAIVPRIGV AEREVPLYVN GPPIISSEAV QYAVRGDGGK VECFIGSTPP PDRIAWAWKE NFLEVGTLER YTVERTNSGS GVLSTLTINN VMEADFQTHY NCTAWNSFGP GTAIIQLEER EVLPVGIIAG ATIGASILLI FFFIALVFFL YRRRKGSRKD VTLRKLDIKV ETVNREPLTM HSDREDDTAS VSTATRVMKA IYSSFKDDVD LKQDLRCDTI DTREEYEMKD PTNGYYNVRA HEDRPSSRAV LYADYRAPGP ARFDGRPSSR LSHSSGYAQL NTYSRGPASD YGPEPTPPGP AAPAGTDTTS QLSYENYEKF NSHPFPGAAG YPTYRLGYPQ APPSGLERTP YEAYDPIGKY ATATRFSYTS QHSDYGQRFQ QRMQTHV