KI3S1_HUMAN » Killer cell immunoglobulin-like receptor 3DS1

KI3S1_HUMAN » Killer cell immunoglobulin-like receptor 3DS1
Magnify KI3S1_HUMAN » Killer cell immunoglobulin-like receptor 3DS1Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KI3S1_HUMAN » Killer cell immunoglobulin-like receptor 3DS1 » MHC class I NK cell receptor;Natural killer-associated transcript 10;NKAT-10;
Hydrophobic Thickness 32.8 ± 2.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -23.3 kcal/mol
ΔGfold -11.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 338-364 (334-367)
Pathways

Immune System (Reactome)

PDB none
OPM none
Complexes none
Interactions

1B07, Complex: KI3S1:1B07, PubMed

TYOBP, Complex: KI3S1:TYOBP, PubMed

Domains

AA: 32-110, PDBID: 3VH8, Subunit H, Seq Identity:97%, Immunoglobulin domain

AA: 127-210, PDBID: 3VH8, Subunit H, Seq Identity:96%, Immunoglobulin domain

AA: 227-307, PDBID: 3VH8, Subunit H, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for KI3S1_HUMAN » Killer cell immunoglobulin-like receptor 3DS1
FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

TISSUE SPECIFICITY: Expressed in NK and T-cell lines but not in B- lymphoblastoid cell lines or in a colon carcinoma cell line.

UniProt features for KI3S1_HUMAN » Killer cell immunoglobulin-like receptor 3DS1
SIGNAL 1 21 By similarity.
CHAIN 22 387 Killer cell immunoglobulin-like receptor 3DS1.
DOMAIN 42 102 Ig-like C2-type 1.
DOMAIN 137 202 Ig-like C2-type 2.
DOMAIN 237 300 Ig-like C2-type 3.
DISULFID 49 95 By similarity.
DISULFID 144 195 By similarity.
DISULFID 244 293 By similarity.
Amino Acid Sequence for KI3S1_HUMAN » Killer cell immunoglobulin-like receptor 3DS1
MSLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML YKEDRIHVPI FHGRIFQEGF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPMVIMVTGN HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHKEWI SKDPSRLVGQ IHDGVSKANF SIGSMMRALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGL YEKPSLSAQP GPKVQAGESV TLSCSSRSSY DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNLRHLH ILIGTSVVKI PFTILLFFLL HRWCSNKKNA AVMDQEPAGN RSEQRGF