KI3L3_HUMAN » Killer cell immunoglobulin-like receptor 3DL3

KI3L3_HUMAN » Killer cell immunoglobulin-like receptor 3DL3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KI3L3_HUMAN » Killer cell immunoglobulin-like receptor 3DL3 » CD158 antigen-like family member Z;Killer cell inhibitory receptor 1;
Hydrophobic Thickness 33.6 ± 3.2 Å
Tilt Angle 0 ± 4°
ΔGtransfer -49.6 kcal/mol
ΔGfold -19.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 321-347 (319-350)
Pathways

Antigen processing and presentation (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 32-110, PDBID: 3WYR, Subunit B, Seq Identity:76%, Immunoglobulin domain

AA: 227-307, PDBID: 3H8N, Subunit A, Seq Identity:77%, Immunoglobulin domain

UniProt annotation for KI3L3_HUMAN » Killer cell immunoglobulin-like receptor 3DL3
FUNCTION: Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.
UniProt features for KI3L3_HUMAN » Killer cell immunoglobulin-like receptor 3DL3
SIGNAL 1 25 Potential.
CHAIN 26 410 Killer cell immunoglobulin-like receptor 3DL3.
DOMAIN 42 97 Ig-like C2-type 1.
DOMAIN 137 197 Ig-like C2-type 2.
DOMAIN 237 295 Ig-like C2-type 3.
DISULFID 49 95 Potential.
DISULFID 144 195 Potential.
DISULFID 244 293 Potential.
Amino Acid Sequence for KI3L3_HUMAN » Killer cell immunoglobulin-like receptor 3DL3
MSLMVVSMAC VGFFLLEGPW PHVGGQDKPF LSAWPGTVVS EGQHVTLQCR SRLGFNEFSL SKEDGMPVPE LYNRIFRNSF LMGPVTPAHA GTYRCCSSHP HSPTGWSAPS NPVVIMVTGV HRKPSLLAHP GPLVKSGETV ILQCWSDVRF ERFLLHREGI TEDPLRLIGQ LHDAGSQVNY SMGPMTPALA GTYRCFGSVT HLPYELSAPS DPLDIVVVGL YGKPSLSAQP GPTVQAGENV TLSCSSRSLF DIYHLSREAE AGELRLTAVL RVNGTFQANF PLGPVTHGGN YRCFGSFRAL PHAWSDPSDP LPVSVTGNSR YLHALIGTSV VIIPFAILLF FLLHRWCANK KNAVVMDQEP AGNRTVNRED SDEQDPQEVT YAQLNHCVFT QRKITRPSQR PKTPPTDTSV