KI3L2_HUMAN » Killer cell immunoglobulin-like receptor 3DL2

KI3L2_HUMAN » Killer cell immunoglobulin-like receptor 3DL2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KI3L2_HUMAN » Killer cell immunoglobulin-like receptor 3DL2 » CD158 antigen-like family member K;MHC class I NK cell receptor;Natural killer-associated transcript 4;NKAT-4; p70 natural killer cell receptor clone CL-5;p70 NK receptor CL-5;
Hydrophobic Thickness 34.4 ± 2.4 Å
Tilt Angle 26 ± 3°
ΔGtransfer -31.9 kcal/mol
ΔGfold -26.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 339-364 (334-367)
Pathways

Antigen processing and presentation (KEGG)

Graft-versus-host disease (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 32-110, PDBID: 3VH8, Subunit H, Seq Identity:83%, Immunoglobulin domain

AA: 127-210, PDBID: 3VH8, Subunit H, Seq Identity:89%, Immunoglobulin domain

AA: 227-307, PDBID: 3H8N, Subunit A, Seq Identity:76%, Immunoglobulin domain

UniProt annotation for KI3L2_HUMAN » Killer cell immunoglobulin-like receptor 3DL2
FUNCTION: Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis.
UniProt features for KI3L2_HUMAN » Killer cell immunoglobulin-like receptor 3DL2
SIGNAL 1 21 By similarity.
CHAIN 22 455 Killer cell immunoglobulin-like receptor 3DL2.
DOMAIN 42 102 Ig-like C2-type 1.
DOMAIN 137 202 Ig-like C2-type 2.
DOMAIN 237 300 Ig-like C2-type 3.
DISULFID 49 95 By similarity.
DISULFID 144 195 By similarity.
DISULFID 244 293 By similarity.
Amino Acid Sequence for KI3L2_HUMAN » Killer cell immunoglobulin-like receptor 3DL2
MSLTVVSMAC VGFFLLQGAW PLMGGQDKPF LSARPSTVVP RGGHVALQCH YRRGFNNFML YKEDRSHVPI FHGRIFQESF IMGPVTPAHA GTYRCRGSRP HSLTGWSAPS NPLVIMVTGN HRKPSLLAHP GPLLKSGETV ILQCWSDVMF EHFFLHREGI SEDPSRLVGQ IHDGVSKANF SIGPLMPVLA GTYRCYGSVP HSPYQLSAPS DPLDIVITGL YEKPSLSAQP GPTVQAGENV TLSCSSWSSY DIYHLSREGE AHERRLRAVP KVNRTFQADF PLGPATHGGT YRCFGSFRAL PCVWSNSSDP LLVSVTGNPS SSWPSPTEPS SKSGICRHLH VLIGTSVVIF LFILLLFFLL YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ LDHCVFIQRK ISRPSQRPKT PLTDTSVYTE LPNAEPRSKV VSCPRAPQSG LEGVF