KI3L1_HUMAN » Killer cell immunoglobulin-like receptor 3DL1

KI3L1_HUMAN » Killer cell immunoglobulin-like receptor 3DL1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KI3L1_HUMAN » Killer cell immunoglobulin-like receptor 3DL1 » CD158 antigen-like family member E;HLA-BW4-specific inhibitory NK cell receptor;MHC class I NK cell receptor;Natural killer-associated transcript 3;NKAT-3; p70 natural killer cell receptor clones CL-2/CL-11;p70 NK receptor CL-2/CL-11;
Hydrophobic Thickness 38.4 ± 3.4 Å
Tilt Angle 0 ± 1°
ΔGtransfer -51.5 kcal/mol
ΔGfold -27.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 339-364 (336-367)
Pathways

Antigen processing and presentation (KEGG)

Graft-versus-host disease (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

PDB 3vh8 (G/H=22-320), 3wuw (G=28-313)
OPM none
Complexes

KI3L1:1B57:IGKC:B2MG_HUMAN

Interactions

1B07, Complex: 1B07:KI3L1, PubMed

1B57, Complex: KI3L1:1B57:IGKC:B2MG, PDBID: 3VH8

Domains

AA: 32-110, PDBID: 3VH8, Subunit H, Seq Identity:100%, Immunoglobulin domain

AA: 127-210, PDBID: 3VH8, Subunit H, Seq Identity:100%, Immunoglobulin domain

AA: 227-307, PDBID: 3VH8, Subunit H, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for KI3L1_HUMAN » Killer cell immunoglobulin-like receptor 3DL1
FUNCTION: Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.

DOMAIN: Ig-like C2-type domain 2 mediates specificity through recognition of the Bw4 epitope.

UniProt features for KI3L1_HUMAN » Killer cell immunoglobulin-like receptor 3DL1
SIGNAL 1 21 By similarity.
CHAIN 22 444 Killer cell immunoglobulin-like receptor 3DL1.
DOMAIN 42 102 Ig-like C2-type 1.
DOMAIN 137 202 Ig-like C2-type 2.
DOMAIN 237 300 Ig-like C2-type 3.
DISULFID 49 95 By similarity.
DISULFID 144 195 By similarity.
DISULFID 244 293 By similarity.
Amino Acid Sequence for KI3L1_HUMAN » Killer cell immunoglobulin-like receptor 3DL1
MSLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML YKEDRIHIPI FHGRIFQESF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPVVIMVTGN HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF SIGPMMLALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV TLSCSSRSSY DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH ILIGTSVVII LFILLLFFLL HLWCSNKKNA AVMDQEPAGN RTANSEDSDE QDPEEVTYAQ LDHCVFTQRK ITRPSQRPKT PPTDTILYTE LPNAKPRSKV VSCP