KI2S5_HUMAN » Killer cell immunoglobulin-like receptor 2DS5

KI2S5_HUMAN » Killer cell immunoglobulin-like receptor 2DS5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KI2S5_HUMAN » Killer cell immunoglobulin-like receptor 2DS5 » CD158 antigen-like family member G;MHC class I NK cell receptor;Natural killer-associated transcript 9;NKAT-9;
Hydrophobic Thickness 33.6 ± 2.4 Å
Tilt Angle 26 ± 9°
ΔGtransfer -24.0 kcal/mol
ΔGfold -10.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 244-269 (241-272)
Pathways

Antigen processing and presentation (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 32-115, PDBID: 1IM9, Subunit D, Seq Identity:93%, Immunoglobulin domain

AA: 132-213, PDBID: 1IM9, Subunit D, Seq Identity:92%, Immunoglobulin domain

UniProt annotation for KI2S5_HUMAN » Killer cell immunoglobulin-like receptor 2DS5
FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
UniProt features for KI2S5_HUMAN » Killer cell immunoglobulin-like receptor 2DS5
SIGNAL 1 21 By similarity.
CHAIN 22 304 Killer cell immunoglobulin-like receptor 2DS5.
DOMAIN 42 107 Ig-like C2-type 1.
DOMAIN 142 205 Ig-like C2-type 2.
DISULFID 49 100 By similarity.
DISULFID 149 198 By similarity.
Amino Acid Sequence for KI2S5_HUMAN » Killer cell immunoglobulin-like receptor 2DS5
MLLMVISMAC VAFFLLQGAW PHEGFRRKPS LLAHPGPLVK SEETVILQCW SDVMFEHFLL HREGTFNHTL RLIGEHIDGV SKGNFSIGRM TQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LPAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHERR LPAGPKVNRT FQADSPLDPA THGGAYRCFG SFRDSPYEWS KSSDPLLVSV TGNSSNSWPS PTEPSSETGN PRHLHVLIGT SVVKLPFTIL LFFLLHRWCS NKKNASVMDQ GPAGNRTVNR EDSDEQDHQE VSYA