KI2S4_HUMAN » Killer cell immunoglobulin-like receptor 2DS4

KI2S4_HUMAN » Killer cell immunoglobulin-like receptor 2DS4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KI2S4_HUMAN » Killer cell immunoglobulin-like receptor 2DS4 » CD158 antigen-like family member I;MHC class I NK cell receptor;Natural killer-associated transcript 8;NKAT-8; P58 natural killer cell receptor clones CL-39/CL-17;p58 NK receptor CL-39/CL-17;
Hydrophobic Thickness 32.4 ± 2.4 Å
Tilt Angle 1 ± 0°
ΔGtransfer -22.8 kcal/mol
ΔGfold -10.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 244-269 (241-272)
Pathways

Antigen processing and presentation (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

PDB 3h8n (27-221)
OPM none
Complexes none
Interactions none
Domains

AA: 32-115, PDBID: 3H8N, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 132-213, PDBID: 3H8N, Subunit A, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for KI2S4_HUMAN » Killer cell immunoglobulin-like receptor 2DS4
FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
UniProt features for KI2S4_HUMAN » Killer cell immunoglobulin-like receptor 2DS4
SIGNAL 1 21 By similarity.
CHAIN 22 304 Killer cell immunoglobulin-like receptor 2DS4.
DOMAIN 42 107 Ig-like C2-type 1.
DOMAIN 142 205 Ig-like C2-type 2.
DISULFID 49 100
DISULFID 149 198
Amino Acid Sequence for KI2S4_HUMAN » Killer cell immunoglobulin-like receptor 2DS4
MSLMVIIMAC VGFFLLQGAW PQEGVHRKPS FLALPGHLVK SEETVILQCW SDVMFEHFLL HREGKFNNTL HLIGEHHDGV SKANFSIGPM MPVLAGTYRC YGSVPHSPYQ LSAPSDPLDM VIIGLYEKPS LSAQPGPTVQ AGENVTLSCS SRSSYDMYHL SREGEAHERR LPAVRSINGT FQADFPLGPA THGGTYRCFG SFRDAPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHVLIGT SVVKIPFTIL LFFLLHRWCS DKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE VSYA