KI2S3_HUMAN » Killer cell immunoglobulin-like receptor 2DS3

KI2S3_HUMAN » Killer cell immunoglobulin-like receptor 2DS3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KI2S3_HUMAN » Killer cell immunoglobulin-like receptor 2DS3 » MHC class I NK cell receptor;Natural killer-associated transcript 7;NKAT-7;
Hydrophobic Thickness 33.2 ± 3.0 Å
Tilt Angle 31 ± 10°
ΔGtransfer -24.0 kcal/mol
ΔGfold -10.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 244-269 (241-272)
Pathways

Antigen processing and presentation (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

PDB none
OPM none
Complexes none
Interactions

TYOBP, Complex: KI2S3:TYOBP, PubMed

Domains

AA: 32-115, PDBID: 1IM9, Subunit D, Seq Identity:88%, Immunoglobulin domain

AA: 132-213, PDBID: 1IM9, Subunit D, Seq Identity:93%, Immunoglobulin domain

UniProt annotation for KI2S3_HUMAN » Killer cell immunoglobulin-like receptor 2DS3
FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
UniProt features for KI2S3_HUMAN » Killer cell immunoglobulin-like receptor 2DS3
SIGNAL 1 21 By similarity.
CHAIN 22 304 Killer cell immunoglobulin-like receptor 2DS3.
DOMAIN 42 107 Ig-like C2-type 1.
DOMAIN 142 205 Ig-like C2-type 2.
DISULFID 49 100 By similarity.
DISULFID 149 198 By similarity.
Amino Acid Sequence for KI2S3_HUMAN » Killer cell immunoglobulin-like receptor 2DS3
MSLMVISMAC VGFFWLQGAW PHEGFRRKPS LLAHPGRLVK SEETVILQCW SDVMFEHFLL HREGTFNDTL RLIGEHIDGV SKANFSIGRM RQDLAGTYRC YGSVPHSPYQ FSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS SWSSYDMYHL STEGEAHERR FSAGPKVNGT FQADFPLGPA TQGGTYRCFG SFHDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHVLIGT SVVKLPFTIL LFFLLHRWCS DKKNASVMDQ GPAGNRTVNR EDSDEQDHQE VSYA