KI2S2_HUMAN » Killer cell immunoglobulin-like receptor 2DS2

KI2S2_HUMAN » Killer cell immunoglobulin-like receptor 2DS2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KI2S2_HUMAN » Killer cell immunoglobulin-like receptor 2DS2 » CD158 antigen-like family member J;MHC class I NK cell receptor;NK receptor 183 ActI;Natural killer-associated transcript 5;NKAT-5; p58 natural killer cell receptor clone CL-49;p58 NK receptor CL-49;
Hydrophobic Thickness 32.4 ± 2.4 Å
Tilt Angle 1 ± 0°
ΔGtransfer -22.8 kcal/mol
ΔGfold -10.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 244-269 (241-272)
Pathways

Antigen processing and presentation (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

PDB 1m4k (22-221), 4n8v (G/I=22-221)
OPM none
Complexes

KI2S2:A14:1A11:B2MG_HUMAN

Interactions

1A11, Complex: KI2S2:A14:1A11:B2MG, PDBID: 4N8V

1C07, Complex: 1C07:KI2S2

TYOBP, Complex: TYOBP:KI2S2, PubMed

Domains

AA: 32-115, PDBID: 1M4K, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 132-213, PDBID: 1B6U, Subunit A, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for KI2S2_HUMAN » Killer cell immunoglobulin-like receptor 2DS2
FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
UniProt features for KI2S2_HUMAN » Killer cell immunoglobulin-like receptor 2DS2
SIGNAL 1 21 By similarity.
CHAIN 22 304 Killer cell immunoglobulin-like receptor 2DS2.
DOMAIN 42 107 Ig-like C2-type 1.
DOMAIN 142 205 Ig-like C2-type 2.
DISULFID 49 100
DISULFID 149 198
Amino Acid Sequence for KI2S2_HUMAN » Killer cell immunoglobulin-like receptor 2DS2
MSLMVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW SDVRFEHFLL HREGKYKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHERR FSAGPKVNGT FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHVLIGT SVVKIPFTIL LFFLLHRWCS NKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE VSYA