KI2S1_HUMAN » Killer cell immunoglobulin-like receptor 2DS1

KI2S1_HUMAN » Killer cell immunoglobulin-like receptor 2DS1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KI2S1_HUMAN » Killer cell immunoglobulin-like receptor 2DS1 » CD158 antigen-like family member H;MHC class I NK cell receptor Eb6 ActI;
Hydrophobic Thickness 32.4 ± 2.4 Å
Tilt Angle 1 ± 0°
ΔGtransfer -22.8 kcal/mol
ΔGfold -10.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 244-269 (241-272)
Pathways

Antigen processing and presentation (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 32-115, PDBID: 1IM9, Subunit D, Seq Identity:96%, Immunoglobulin domain

AA: 132-213, PDBID: 1IM9, Subunit D, Seq Identity:96%, Immunoglobulin domain

UniProt annotation for KI2S1_HUMAN » Killer cell immunoglobulin-like receptor 2DS1
FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
UniProt features for KI2S1_HUMAN » Killer cell immunoglobulin-like receptor 2DS1
SIGNAL 1 21 By similarity.
CHAIN 22 304 Killer cell immunoglobulin-like receptor 2DS1.
DOMAIN 42 107 Ig-like C2-type 1.
DOMAIN 142 205 Ig-like C2-type 2.
DISULFID 49 100 By similarity.
DISULFID 149 198 By similarity.
Amino Acid Sequence for KI2S1_HUMAN » Killer cell immunoglobulin-like receptor 2DS1
MSLTVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW SDVMFEHFLL HREGMFNDTL RLIGEHHDGV SKANFSISRM RQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI VIIGLYEKPS LSAQPGPTVL AGENVTLSCS SRSSYDMYHL SREGEAHERR LPAGTKVNGT FQANFPLGPA THGGTYRCFG SFRDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSETGN PRHLHVLIGT SVVKIPFTIL LFFLLHRWCS DKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE VSYA