KI2LB_HUMAN » Killer cell immunoglobulin-like receptor 2DL5B

KI2LB_HUMAN » Killer cell immunoglobulin-like receptor 2DL5B
Magnify KI2LB_HUMAN » Killer cell immunoglobulin-like receptor 2DL5BEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KI2LB_HUMAN » Killer cell immunoglobulin-like receptor 2DL5B » CD158 antigen-like family member F2;Killer cell immunoglobulin-like receptor 2DLX;
Hydrophobic Thickness 34.4 ± 3.0 Å
Tilt Angle 21 ± 7°
ΔGtransfer -29.2 kcal/mol
ΔGfold -24.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 239-263 (234-268)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 32-110, PDBID: 3WYR, Subunit B, Seq Identity:82%, Immunoglobulin domain

AA: 127-207, PDBID: 1IM9, Subunit D, Seq Identity:82%, Immunoglobulin domain

UniProt annotation for KI2LB_HUMAN » Killer cell immunoglobulin-like receptor 2DL5B
FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.
UniProt features for KI2LB_HUMAN » Killer cell immunoglobulin-like receptor 2DL5B
SIGNAL 1 21 Potential.
CHAIN 22 375 Killer cell immunoglobulin-like receptor 2DL5B.
DOMAIN 42 102 Ig-like C2-type 1.
DOMAIN 137 200 Ig-like C2-type 2.
DISULFID 49 95 By similarity.
DISULFID 144 193 By similarity.
Amino Acid Sequence for KI2LB_HUMAN » Killer cell immunoglobulin-like receptor 2DL5B
MSLMVISMAC VGFFLLQGAW THEGGQDKPL LSAWPSAVVP RGGHVTLLCR SRLGFTIFSL YKEDGVPVPE LYNKIFWKSI LMGPVTPAHA GTYRCRGSHP RSPIEWSAPS NPLVIVVTGL FGKPSLSAQP GPTVRTGENV ALSCSSRSSF DMYHLSREGR AHEPRLPAVP SVDGTFQADF PLGPATHGGT YTCFSSLHDS PYEWSDPSDP LLVSVTGNSS SSSSSPTEPS SKTGIRRHLH ILIGTSVAII LFIILFFFLL HCCCSNKKNA AVMDQGPAGD RTVNREDSDD QDPQEVTYAQ LDHCVFTQTK ITSPSQRPKT PPTDTTMYME LPNAKPRSLS PAHKHHSQAL RGSSRETTAL SQNRVASSHV PAAGI