KI2LA_HUMAN » Killer cell immunoglobulin-like receptor 2DL5A

KI2LA_HUMAN » Killer cell immunoglobulin-like receptor 2DL5A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KI2LA_HUMAN » Killer cell immunoglobulin-like receptor 2DL5A »
Hydrophobic Thickness 36.8 ± 3.6 Å
Tilt Angle 1 ± 4°
ΔGtransfer -50.9 kcal/mol
ΔGfold -24.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 239-263 (234-268)
Pathways

Antigen processing and presentation (KEGG)

Graft-versus-host disease (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 32-110, PDBID: 3WYR, Subunit B, Seq Identity:82%, Immunoglobulin domain

AA: 127-207, PDBID: 1IM9, Subunit D, Seq Identity:85%, Immunoglobulin domain

UniProt annotation for KI2LA_HUMAN » Killer cell immunoglobulin-like receptor 2DL5A
FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.
UniProt features for KI2LA_HUMAN » Killer cell immunoglobulin-like receptor 2DL5A
SIGNAL 1 21 Potential.
CHAIN 22 375 Killer cell immunoglobulin-like receptor 2DL5A.
DOMAIN 42 102 Ig-like C2-type 1.
DOMAIN 137 200 Ig-like C2-type 2.
DISULFID 49 95 By similarity.
DISULFID 144 193 By similarity.
Amino Acid Sequence for KI2LA_HUMAN » Killer cell immunoglobulin-like receptor 2DL5A
MSLMVISMAC VGFFLLQGAW THEGGQDKPL LSAWPSAVVP RGGHVTLLCR SRLGFTIFSL YKEDGVPVPE LYNKIFWKSI LMGPVTPAHA GTYRCRGSHP RSPIEWSAPS NPLVIVVTGL FGKPSLSAQP GPTVRTGENV TLSCSSRSSF DMYHLSREGR AHEPRLPAVP SVNGTFQADF PLGPATHGGT YTCFGSLHDS PYEWSDPSDP LLVSVTGNSS SSSSSPTEPS SKTGIRRHLH ILIGTSVAII LFIILFFFLL HCCCSNKKNA AVMDQEPAGD RTVNREDSDD QDPQEVTYAQ LDHCVFTQTK ITSPSQRPKT PPTDTTMYME LPNAKPRSLS PAHKHHSQAL RGSSRETTAL SQNRVASSHV PAAGI