KI2L4_HUMAN » Killer cell immunoglobulin-like receptor 2DL4

KI2L4_HUMAN » Killer cell immunoglobulin-like receptor 2DL4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KI2L4_HUMAN » Killer cell immunoglobulin-like receptor 2DL4 » CD158 antigen-like family member D;G9P;Killer cell inhibitory receptor 103AS;KIR-103AS; MHC class I NK cell receptor KIR103AS;
Hydrophobic Thickness 32.0 ± 3.0 Å
Tilt Angle 9 ± 9°
ΔGtransfer -23.5 kcal/mol
ΔGfold -16.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 244-266 (238-273)
Pathways

Antigen processing and presentation (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

PDB none
OPM none
Complexes none
Interactions

FCERG, Complex: FCERG:KI2L4, PubMed

HLAG, Complex: KI2L4:HLAG, PubMed

Domains

AA: 34-112, PDBID: 3WYR, Subunit B, Seq Identity:100%, Immunoglobulin domain

AA: 129-209, PDBID: 3WYR, Subunit B, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for KI2L4_HUMAN » Killer cell immunoglobulin-like receptor 2DL4
FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.

SUBUNIT: Interacts with ARRB2.

UniProt features for KI2L4_HUMAN » Killer cell immunoglobulin-like receptor 2DL4
SIGNAL 1 21 By similarity.
CHAIN 22 377 Killer cell immunoglobulin-like receptor 2DL4.
DOMAIN 44 104 Ig-like C2-type 1.
DOMAIN 139 202 Ig-like C2-type 2.
DISULFID 51 97 By similarity.
DISULFID 146 195 By similarity.
Amino Acid Sequence for KI2L4_HUMAN » Killer cell immunoglobulin-like receptor 2DL4
MSMSPTVIIL ACLGFFLDQS VWAHVGGQDK PFCSAWPSAV VPQGGHVTLR CHYRRGFNIF TLYKKDGVPV PELYNRIFWN SFLISPLTPA HAGTYRCRGF HPHSPTEWSA PSNPLVIMVT GLYEKPSLTA RPGPTVRTGE NVTLSCSSQS SFDIYHLSRE GEAHELRLPA VPSINGTFQA DFPLGPATHG ETYRCFGSFH GSPYEWSDAS DPLPVSVTGN PSSSWPSPTE PSFKTGIARH LHAVIRYSVA IILFTILPFF LLHRWCSKKK DAAVMNQEPA GHRTVNREDS DEQDPQEVTY AQLDHCIFTQ RKITGPSQRS KRPSTDTSVC IELPNAEPRA LSPAHEHHSQ ALMGSSRETT ALSQTQLASS HVPAAGI