KI2L3_HUMAN » Killer cell immunoglobulin-like receptor 2DL3

KI2L3_HUMAN » Killer cell immunoglobulin-like receptor 2DL3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KI2L3_HUMAN » Killer cell immunoglobulin-like receptor 2DL3 » CD158 antigen-like family member B2;KIR-023GB;Killer inhibitory receptor cl 2-3;MHC class I NK cell receptor;NKAT2a;NKAT2b;Natural killer-associated transcript 2;NKAT-2; p58 natural killer cell receptor clone CL-6;p58 NK receptor CL-6; p58.2 MHC class-I-s
Hydrophobic Thickness 33.4 ± 2.2 Å
Tilt Angle 1 ± 6°
ΔGtransfer -27.1 kcal/mol
ΔGfold -23.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 244-266 (241-266)
Pathways

Antigen processing and presentation (KEGG)

Graft-versus-host disease (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)
PDB 1b6u (A=22-245)
OPM none
Complexes none
Interactions

1C07, Complex: 1C07:KI2L3

A4, Complex: KI2L3:A4, PubMed
Domains

AA: 32-115, PDBID: 1B6U, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 132-213, PDBID: 1B6U, Subunit A, Seq Identity:100%, Immunoglobulin domain
UniProt annotation for KI2L3_HUMAN » Killer cell immunoglobulin-like receptor 2DL3
FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.

SUBUNIT: Interacts with ARRB2.

UniProt features for KI2L3_HUMAN » Killer cell immunoglobulin-like receptor 2DL3
SIGNAL 1 21 By similarity.
CHAIN 22 341 Killer cell immunoglobulin-like receptor 2DL3.
DOMAIN 42 107 Ig-like C2-type 1.
DOMAIN 142 205 Ig-like C2-type 2.
DISULFID 49 100 By similarity.
DISULFID 149 198 By similarity.
Amino Acid Sequence for KI2L3_HUMAN » Killer cell immunoglobulin-like receptor 2DL3
MSLMVVSMVC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW SDVRFQHFLL HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHERR FSAGPKVNGT FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSETGN PRHLHVLIGT SVVIILFILL LFFLLHRWCC NKKNAVVMDQ EPAGNRTVNR EDSDEQDPQE VTYAQLNHCV FTQRKITRPS QRPKTPPTDI IVYTELPNAE P