KI2L2_HUMAN » Killer cell immunoglobulin-like receptor 2DL2

KI2L2_HUMAN » Killer cell immunoglobulin-like receptor 2DL2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KI2L2_HUMAN » Killer cell immunoglobulin-like receptor 2DL2 » CD158 antigen-like family member B1;MHC class I NK cell receptor;Natural killer-associated transcript 6;NKAT-6; p58 natural killer cell receptor clone CL-43;p58 NK receptor CL-43;
Hydrophobic Thickness 34.0 ± 2.4 Å
Tilt Angle 23 ± 6°
ΔGtransfer -30.5 kcal/mol
ΔGfold -23.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 244-268 (241-271)
Pathways

Antigen processing and presentation (KEGG)

Graft-versus-host disease (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

PDB 2dli (25-221), 2dl2 (26-221), 1efx (D/E=22-221)
OPM none
Complexes

1C03:KI2L2:IMA1:B2MG_HUMAN

Interactions

1C03, Complex: 1C03:B2MG:IMA2:KI2L2, PDBID: 1efx

1C07, Complex: 1C07:KI2L2

C1QR1, Complex: C1QR1:KI2L2, PubMed

Domains

AA: 32-115, PDBID: 1EFX, Subunit E, Seq Identity:100%, Immunoglobulin domain

AA: 132-213, PDBID: 1EFX, Subunit E, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for KI2L2_HUMAN » Killer cell immunoglobulin-like receptor 2DL2
FUNCTION: Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis.
UniProt features for KI2L2_HUMAN » Killer cell immunoglobulin-like receptor 2DL2
SIGNAL 1 21 By similarity.
CHAIN 22 348 Killer cell immunoglobulin-like receptor 2DL2.
DOMAIN 42 107 Ig-like C2-type 1.
DOMAIN 142 205 Ig-like C2-type 2.
DISULFID 49 100
DISULFID 149 198
Amino Acid Sequence for KI2L2_HUMAN » Killer cell immunoglobulin-like receptor 2DL2
MSLMVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW SDVRFEHFLL HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHECR FSAGPKVNGT FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV IGNPSNSWPS PTEPSSKTGN PRHLHILIGT SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYAELPNAES RSKVVSCP