KI2L1_HUMAN » Killer cell immunoglobulin-like receptor 2DL1

KI2L1_HUMAN » Killer cell immunoglobulin-like receptor 2DL1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
KI2L1_HUMAN » Killer cell immunoglobulin-like receptor 2DL1 » CD158 antigen-like family member A;MHC class I NK cell receptor;Natural killer-associated transcript 1;NKAT-1; p58 natural killer cell receptor clones CL-42/47.11;p58 NK receptor CL-42/47.11; p58.1 MHC class-I-specific NK receptor;
Hydrophobic Thickness 34.0 ± 2.4 Å
Tilt Angle 23 ± 6°
ΔGtransfer -30.5 kcal/mol
ΔGfold -23.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 244-268 (241-271)
Pathways

Antigen processing and presentation (KEGG)

Graft-versus-host disease (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

PDB 1nkr (22-221), 1im9 (D=22-245)
OPM none
Complexes

KI2L1:1C04:B2MG_HUMAN

Interactions

1C04, Complex: 1C04:B2MG:KI2L1, PDBID: 1im9

1C07, Complex: 1C07:KI2L1

Domains

AA: 32-115, PDBID: 1IM9, Subunit D, Seq Identity:100%, Immunoglobulin domain

AA: 132-213, PDBID: 1IM9, Subunit D, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for KI2L1_HUMAN » Killer cell immunoglobulin-like receptor 2DL1
FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.

SUBUNIT: Interacts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11; the interaction is enhanced by ARRB2.

UniProt features for KI2L1_HUMAN » Killer cell immunoglobulin-like receptor 2DL1
SIGNAL 1 21
CHAIN 22 348 Killer cell immunoglobulin-like receptor 2DL1.
DOMAIN 42 107 Ig-like C2-type 1.
DOMAIN 142 205 Ig-like C2-type 2.
DISULFID 49 100
DISULFID 149 198
Amino Acid Sequence for KI2L1_HUMAN » Killer cell immunoglobulin-like receptor 2DL1
MSLLVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW SDVMFEHFLL HREGMFNDTL RLIGEHHDGV SKANFSISRM TQDLAGTYRC YGSVTHSPYQ VSAPSDPLDI VIIGLYEKPS LSAQPGPTVL AGENVTLSCS SRSSYDMYHL SREGEAHERR LPAGPKVNGT FQADFPLGPA THGGTYRCFG SFHDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHILIGT SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYTELPNAES RSKVVSCP