KASH5_HUMAN » Protein KASH5

KASH5_HUMAN » Protein KASH5
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Topology in Nuclear outer membrane
Topologyintermembrane space
cytoplasmic side
KASH5_HUMAN » Protein KASH5 » Coiled-coil domain-containing protein 155;KASH domain-containing protein 5;
Hydrophobic Thickness 30.0 ± 3.0 Å
Tilt Angle 14 ± 8°
ΔGtransfer -23.2 kcal/mol
ΔGfold -12.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 522-541 (522-542)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ABHD1, Complex: ABHD1:KASH5

B2CL2, Complex: B2CL2:KASH5

BET1, Complex: BET1:KASH5

CK075, Complex: KASH5:SMCO4

CXL16, Complex: CXL16:KASH5

FATE1, Complex: KASH5:FATE1

FIS1, Complex: FIS1:KASH5

GALT2, Complex: GALT2:KASH5

GOSR2, Complex: GOSR2:KASH5

HMOX1, Complex: KASH5:HMOX1

ITM2B, Complex: ITM2B:KASH5

MMP14, Complex: MMP14:KASH5

NSG1, Complex: NSG1:KASH5

PGFRA, Complex: PGFRA:KASH5

RTP2, Complex: RTP2:KASH5

SARCO, Complex: SARCO:KASH5

SERP2, Complex: SERP2:KASH5

STBD1, Complex: STBD1:KASH5

STX5, Complex: STX5:KASH5

T3JAM, Complex: KASH5:T3JAM

TMPS4, Complex: TMPS4:KASH5

UPK2, Complex: UPK2:KASH5

VAMP1, Complex: VAMP1:KASH5

VAMP4, Complex: VAMP4:KASH5

Domains

AA: 38-105, EF-hand domain

AA: 157-347, Coiled-coil region of CCDC155 or KASH

UniProt annotation for KASH5_HUMAN » Protein KASH5
FUNCTION: May be involved in meiotic chromosome dynamics and homolog pairing.

SUBUNIT: Interacts (via the last 22 AA) with SUN1; this interaction mediates telomere localization. Interacts with dynein- dynactin motor complex.

DOMAIN: The C-terminal 22 AA is required and sufficient for localization to telomeres at the nuclear envelope.

UniProt features for KASH5_HUMAN » Protein KASH5
CHAIN 1 562 Protein KASH5.
COILED 164 349 Potential.
Amino Acid Sequence for KASH5_HUMAN » Protein KASH5
MDLPEGPVGG PTAEMYLRER PEEARLGMPV SLEEQILNST FEACDPQRTG TVAVAQVLAY LEAVTGQGPQ DARLQTLANS LDPNGEGPKA TVDLDTFLVV MRDWIAACQL HGGLELEEET AFQGALTSRQ LPSGCPEAEE PANLESFGGE DPRPELQATA DLLSSLEDLE LSNRRLVGEN AKLQRSMETA EEGSARLGEE ILALRKQLHS TQQALQFAKA MDEELEDLKT LARSLEEQNR SLLAQARQAE KEQQHLVAEM ETLQEENGKL LAERDGVKKR SQELAMEKDT LKRQLFECEH LICQRDTILS ERTRDVESLA QTLEEYRVTT QELRLEISRL EEQLSQTYEG PDELPEGAQL RRVGWTELLP PSLGLEIEAI RQKQEVATAD LSNPLCGVWQ WEEVIHETSE ETEFPSEAPA GGQRNFQGEP AHPEEGRKEP SMWLTRREEE EDAESQVTAD LPVPLGAPRP GDIPENPPER PARRELQQAL VPVMKKLVPV RRRAWGQLCL PPQRLRVTRH PLIPAPVLGL LLLLLLSVLL LGPSPPPTWP HLQLCYLQPP PV