JPH1_HUMAN » Junctophilin-1

JPH1_HUMAN » Junctophilin-1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
JPH1_HUMAN » Junctophilin-1 » JP-1; Junctophilin type 1;
Hydrophobic Thickness 32.0 ± 1.4 Å
Tilt Angle 1 ± 0°
ΔGtransfer -41.0 kcal/mol
ΔGfold -16.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 638-660 (637-660)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 14-36, PDBID: 1H3I, Subunit B, Seq Identity:26%, MORN repeat

AA: 38-59, PDBID: 1H3I, Subunit B, Seq Identity:29%, MORN repeat

AA: 60-80, PDBID: 1H3I, Subunit B, Seq Identity:25%, MORN repeat

AA: 82-99, PDBID: 1H3I, Subunit B, Seq Identity:24%, MORN repeat

AA: 106-128, PDBID: 1H3I, Subunit B, Seq Identity:45%, MORN repeat

AA: 129-151, PDBID: 1H3I, Subunit B, Seq Identity:25%, MORN repeat

AA: 281-303, PDBID: 1H3I, Subunit B, Seq Identity:28%, MORN repeat

AA: 304-326, PDBID: 1H3I, Subunit B, Seq Identity:40%, MORN repeat

UniProt annotation for JPH1_HUMAN » Junctophilin-1
FUNCTION: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.

TISSUE SPECIFICITY: Abundantly expressed in skeletal muscle. Very low levels in heart.

DOMAIN: The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids.

UniProt features for JPH1_HUMAN » Junctophilin-1
CHAIN 1 661 Junctophilin-1.
REPEAT 14 36 MORN 1.
REPEAT 38 59 MORN 2.
REPEAT 60 82 MORN 3.
REPEAT 106 128 MORN 4.
REPEAT 129 151 MORN 5.
REPEAT 281 303 MORN 6.
REPEAT 304 326 MORN 7.
Amino Acid Sequence for JPH1_HUMAN » Junctophilin-1
MTGGRFDFDD GGTYCGGWEE GKAHGHGICT GPKGQGEYSG SWSHGFEVVG GYTWPSGNTY QGYWAQGKRH GLGVETKGKW MYRGEWSHGF KGRYGVRQSL CTPARYEGTW SNGLQDGYGV ETYGDGGTYQ GQWAGGMRHG YGVRQSVPYG MATVIRSPLR TSLASLRSEQ SNGSVLHDAA AAADSPAGTR GGFVLNFHAD AELAGKKKGG LFRRGSLLGS MKLRKSESKS SISSKRSSVR SDAAMSRISS SDANSTISFG DVDCDFCPVE DHVDATTTET YMGEWKNDKR NGFGVSERSN GMKYEGEWAN NKRHGYGCTV FPDGSKEEGK YKNNILVRGI RKQLIPIRHT KTREKVDRAI EGAQRAAAMA RTKVEIANSR TAHARAKADA ADQAALAARQ ECDIARAVAR ELSPDFYQPG PDYVKQRFQE GVDAKENPEE KVPEKPPTPK ESPHFYRKGT TPPRSPEASP KHSHSPASSP KPLKKQNPSS GARLNQDKRS VADEQVTAIV NKPLMSKAPT KEAGAVVPQS KYSGRHHIPN PSNGELHSQY HGYYVKLNAP QHPPVDVEDG DGSSQSSSAL VHKPSANKWS PSKSVTKPVA KESKAEPKAK KSELAIPKNP ASNDSCPALE KEANSGPNSI MIVLVMLLNI GLAILFVHFL T