JAML1_HUMAN » Junctional adhesion molecule-like

JAML1_HUMAN » Junctional adhesion molecule-like
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
JAML1_HUMAN » Junctional adhesion molecule-like » Adhesion molecule interacting with CXADR antigen 1;Dendritic cell-specific protein CREA7-1;
Hydrophobic Thickness 32.8 ± 1.0 Å
Tilt Angle 1 ± 2°
ΔGtransfer -41.5 kcal/mol
ΔGfold -20.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 274-299 (272-299)
Pathways

Hemostasis (Reactome)

Immune System (Reactome)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes

CXAR:JAML1_MOUSE

Interactions

CXAR, Complex: CXAR:JAML1, PDBID: 3MJ7

Domains

AA: 25-136, PDBID: 3MJ6, Subunit A, Seq Identity:62%, Immunoglobulin V-set domain

AA: 138-252, PDBID: 3MJ6, Subunit A, Seq Identity:54%, Immunoglobulin V-set domain

UniProt annotation for JAML1_HUMAN » Junctional adhesion molecule-like
FUNCTION: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.

SUBUNIT: Homodimer; active form in leukocyte-endothelial cell adhesion. Interacts (homodimeric form) with CXADR. Interacts (via cytoplasmic domain) with the PI3 kinase; upon CXADR-binding. Interacts with ITGA4 and ITGB1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling AMICA1 homodimerization.

TISSUE SPECIFICITY: Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level).

INDUCTION: Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells.

DOMAIN: The Ig-like V-type domain 1 mediates interaction with CXADR (By similarity). The Ig-like V-type domain 2 may also play a role in the interaction (PubMed).

UniProt features for JAML1_HUMAN » Junctional adhesion molecule-like
SIGNAL 1 19
CHAIN 20 394 Junctional adhesion molecule-like.
DOMAIN 20 132 Ig-like V-type 1.
DOMAIN 137 250 Ig-like V-type 2.
DISULFID 42 116 By similarity.
DISULFID 155 234 By similarity.
Amino Acid Sequence for JAML1_HUMAN » Junctional adhesion molecule-like
MFCPLKLILL PVLLDYSLGL NDLNVSPPEL TVHVGDSALM GCVFQSTEDK CIFKIDWTLS PGEHAKDEYV LYYYSNLSVP IGRFQNRVHL MGDILCNDGS LLLQDVQEAD QGTYICEIRL KGESQVFKKA VVLHVLPEEP KELMVHVGGL IQMGCVFQST EVKHVTKVEW IFSGRRAKEE IVFRYYHKLR MSVEYSQSWG HFQNRVNLVG DIFRNDGSIM LQGVRESDGG NYTCSIHLGN LVFKKTIVLH VSPEEPRTLV TPAALRPLVL GGNQLVIIVG IVCATILLLP VLILIVKKTC GNKSSVNSTV LVKNTKKTNP EIKEKPCHFE RCEGEKHIYS PIIVREVIEE EEPSEKSEAT YMTMHPVWPS LRSDRNNSLE KKSGGGMPKT QQAF