JAM3_HUMAN » Junctional adhesion molecule C

JAM3_HUMAN » Junctional adhesion molecule C
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
JAM3_HUMAN » Junctional adhesion molecule C » JAM-C; JAM-2;Junctional adhesion molecule 3;JAM-3;
Hydrophobic Thickness 33.6 ± 2.4 Å
Tilt Angle 37 ± 5°
ΔGtransfer -23.8 kcal/mol
ΔGfold -19.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 242-267 (242-269)
Pathways

Cell adhesion molecules (KEGG)

Epithelial cell signaling in Helicobacter pylori infection (KEGG)

Hemostasis (Reactome)

Leukocyte transendothelial migration (KEGG)

Signal Transduction (Reactome)

Tight junction (KEGG)

PDB none
OPM none
Complexes none
Interactions

ITAM, Complex: ITAM:JAM3, PubMed

ITAX, Complex: ITAX:JAM3, PubMed

ITB2, Complex: ITAM:ITB2:JAM3

JAM2, Complex: JAM3:JAM2, PubMed

PKHD1, Complex: PARD3.PKHD1:JAM3, PubMed

Domains

AA: 36-136, PDBID: 1F97, Subunit A, Seq Identity:32%, Immunoglobulin V-set domain

AA: 138-223, PDBID: 1NBQ, Subunit B, Seq Identity:30%, Immunoglobulin domain

UniProt annotation for JAM3_HUMAN » Junctional adhesion molecule C
FUNCTION: Participates in cell-cell adhesion. It is a counter- receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis.

SUBUNIT: Interacts with JAM2. Interacts with ITGAM.

TISSUE SPECIFICITY: Highest expression in placenta, brain and kidney. Significant expression is detected on platelets. Expressed in intestinal mucosa cells. Expressed in the vascular endothelium. Found in serum (at protein level). Also detected in the synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis or ostearthritis (at protein level).

DISEASE: Hemorrhagic destruction of the brain with subependymal calcification and cataracts (HDBSCC) OMIM: A syndrome characterized by congenital cataracts and severe brain abnormalities apparently resulting from hemorrhagic destruction of the brain parenchyma, including the cerebral white matter and basal ganglia. Patients manifest profound developmental delay, and other neurologic features included seizures, spasticity, and hyperreflexia. The clinical course is very severe resulting in death in infancy. Brain imaging shows multifocal intraparenchymal hemorrhage with associated liquefaction and massive cystic degeneration, and calcification in the subependymal region and in brain tissue. mutations affecting the gene represented in this entry.

UniProt features for JAM3_HUMAN » Junctional adhesion molecule C
SIGNAL 1 31
CHAIN 32 310 Junctional adhesion molecule C.
DOMAIN 35 127 Ig-like V-type.
DOMAIN 139 236 Ig-like C2-type.
DISULFID 53 115 Potential.
DISULFID 160 219 Potential.
Amino Acid Sequence for JAM3_HUMAN » Junctional adhesion molecule C
MALRRPPRLR LCARLPDFFL LLLFRGCLIG AVNLKSSNRT PVVQEFESVE LSCIITDSQT SDPRIEWKKI QDEQTTYVFF DNKIQGDLAG RAEILGKTSL KIWNVTRRDS ALYRCEVVAR NDRKEIDEIV IELTVQVKPV TPVCRVPKAV PVGKMATLHC QESEGHPRPH YSWYRNDVPL PTDSRANPRF RNSSFHLNSE TGTLVFTAVH KDDSGQYYCI ASNDAGSARC EEQEMEVYDL NIGGIIGGVL VVLAVLALIT LGICCAYRRG YFINNKQDGE SYKNPGKPDG VNYIRTDEEG DFRHKSSFVI