JAM2_HUMAN » Junctional adhesion molecule B

JAM2_HUMAN » Junctional adhesion molecule B
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
JAM2_HUMAN » Junctional adhesion molecule B » JAM-B; Junctional adhesion molecule 2;JAM-2; Vascular endothelial junction-associated molecule;VE-JAM;
Hydrophobic Thickness 35.2 ± 2.0 Å
Tilt Angle 0 ± 14°
ΔGtransfer -20.7 kcal/mol
ΔGfold -18.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 238-261 (237-264)
Pathways

Cell adhesion molecules (KEGG)

Epithelial cell signaling in Helicobacter pylori infection (KEGG)

Hemostasis (Reactome)

Leukocyte transendothelial migration (KEGG)

Signal Transduction (Reactome)

Tight junction (KEGG)

PDB none
OPM none
Complexes none
Interactions

ITA4, Complex: ITB1:JAM2:ITA4, PubMed

ITB1, Complex: ITB1:JAM2:ITA4, PubMed

JAM3, Complex: JAM3:JAM2, PubMed

PKHD1, Complex: JAM2:PARD3.PKHD1, PubMed

Domains

AA: 33-131, PDBID: 1F97, Subunit A, Seq Identity:33%, Immunoglobulin V-set domain

AA: 136-218, PDBID: 1NBQ, Subunit B, Seq Identity:40%, Immunoglobulin domain

UniProt annotation for JAM2_HUMAN » Junctional adhesion molecule B
FUNCTION: May play a role in the processes of lymphocyte homing to secondary lymphoid organs.

SUBUNIT: Interacts with JAM3.

TISSUE SPECIFICITY: Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells.

UniProt features for JAM2_HUMAN » Junctional adhesion molecule B
SIGNAL 1 28
CHAIN 29 298 Junctional adhesion molecule B.
DOMAIN 32 127 Ig-like V-type.
DOMAIN 134 238 Ig-like C2-type.
DISULFID 50 109 Potential.
DISULFID 155 214 Potential.
Amino Acid Sequence for JAM2_HUMAN » Junctional adhesion molecule B
MARRSRHRLL LLLLRYLVVA LGYHKAYGFS APKDQQVVTA VEYQEAILAC KTPKKTVSSR LEWKKLGRSV SFVYYQQTLQ GDFKNRAEMI DFNIRIKNVT RSDAGKYRCE VSAPSEQGQN LEEDTVTLEV LVAPAVPSCE VPSSALSGTV VELRCQDKEG NPAPEYTWFK DGIRLLENPR LGSQSTNSSY TMNTKTGTLQ FNTVSKLDTG EYSCEARNSV GYRRCPGKRM QVDDLNISGI IAAVVVVALV ISVCGLGVCY AQRKGYFSKE TSFQKSNSSS KATTMSENDF KHTKSFII