JAM1_HUMAN » Junctional adhesion molecule A

JAM1_HUMAN » Junctional adhesion molecule A
Magnify JAM1_HUMAN » Junctional adhesion molecule AEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
JAM1_HUMAN » Junctional adhesion molecule A » JAM-A; Junctional adhesion molecule 1;JAM-1; Platelet F11 receptor;Platelet adhesion molecule 1;PAM-1;
Hydrophobic Thickness 40.0 ± 2.0 Å
Tilt Angle 0 ± 3°
ΔGtransfer -53.2 kcal/mol
ΔGfold -26.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 235-261 (231-265)
Pathways

Cell adhesion molecules (KEGG)

Cell-Cell communication (Reactome)

Epithelial cell signaling in Helicobacter pylori infection (KEGG)

Hemostasis (Reactome)

Leukocyte transendothelial migration (KEGG)

Signal Transduction (Reactome)

Tight junction (KEGG)

PDB 1nbq (A/B=27-233), 3tsz (B=288-299), 3eoy (G/H...=28-129)
OPM none
Complexes

JAM1:JAM1_HUMAN

Interactions

ITAL, Complex: ITAL:JAM1, PubMed

ITAV, Complex: ITB3:ITAV:JAM1, PubMed

ITB3, Complex: ITB3:ITAV:JAM1, PubMed

JAM1, Complex: Homodimer of junctional adhesion molecule A, PDBID: 1NBQ

PKHD1, Complex: JAM1:PARD3.PKHD1, PubMed

PTPRB, Complex: JAM1:PTPRB, PubMed

Domains

AA: 33-124, PDBID: 1NBQ, Subunit B, Seq Identity:100%, Immunoglobulin domain

AA: 134-216, PDBID: 1NBQ, Subunit B, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for JAM1_HUMAN » Junctional adhesion molecule A
FUNCTION: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.

SUBUNIT: Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein (By similarity).

UniProt features for JAM1_HUMAN » Junctional adhesion molecule A
SIGNAL 1 27
CHAIN 28 299 Junctional adhesion molecule A.
DOMAIN 28 125 Ig-like V-type 1.
DOMAIN 135 228 Ig-like V-type 2.
DISULFID 50 109
DISULFID 153 212
Amino Acid Sequence for JAM1_HUMAN » Junctional adhesion molecule A
MGTKAQVERK LLCLFILAIL LCSLALGSVT VHSSEPEVRI PENNPVKLSC AYSGFSSPRV EWKFDQGDTT RLVCYNNKIT ASYEDRVTFL PTGITFKSVT REDTGTYTCM VSEEGGNSYG EVKVKLIVLV PPSKPTVNIP SSATIGNRAV LTCSEQDGSP PSEYTWFKDG IVMPTNPKST RAFSNSSYVL NPTTGELVFD PLSASDTGEY SCEARNGYGT PMTSNAVRME AVERNVGVIV AAVLVTLILL GILVFGIWFA YSRGHFDRTK KGTSSKKVIY SQPSARSEGE FKQTSSFLV