JAG2_HUMAN » Protein jagged-2

JAG2_HUMAN » Protein jagged-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
JAG2_HUMAN » Protein jagged-2 » Jagged2; hJ2;
Hydrophobic Thickness 38.4 ± 2.6 Å
Tilt Angle 4 ± 1°
ΔGtransfer -36.6 kcal/mol
ΔGfold -15.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 1082-1107 (1078-1115)
Pathways

Notch signaling pathway (KEGG)

Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor (Reactome)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

DLL1, Complex: JAG2:DLL1, PubMed

NOTC1, Complex: NOTC1:JAG2, PubMed

NOTC2, Complex: JAG2:NOTC2, PubMed

NOTC3, Complex: NOTC3:JAG2, PubMed

Domains

AA: 27-103, PDBID: 4CBZ, Subunit B, Seq Identity:55%, N terminus of Notch ligand

AA: 178-240, PDBID: 2VJ2, Subunit A, Seq Identity:67%, Delta serrate ligand

AA: 311-343, PDBID: 2VJ2, Subunit A, Seq Identity:67%, EGF-like domain

AA: 351-381, PDBID: 1EDM, Subunit B, Seq Identity:54%, EGF-like domain

AA: 389-419, PDBID: 1TOZ, Subunit A, Seq Identity:50%, EGF-like domain

AA: 423-465, PDBID: 2RQZ, Subunit A, Seq Identity:41%, Calcium-binding EGF domain

AA: 469-490, PDBID: 4D90, Subunit A, Seq Identity:52%, Human growth factor-like EGF

AA: 507-528, PDBID: 2YGQ, Subunit A, Seq Identity:47%, Human growth factor-like EGF

AA: 606-628, PDBID: 2YGQ, Subunit A, Seq Identity:41%, Human growth factor-like EGF

AA: 640-670, PDBID: 1BF9, Subunit A, Seq Identity:47%, EGF-like domain

AA: 678-708, PDBID: 4XBM, Subunit B, Seq Identity:48%, EGF-like domain

AA: 716-746, PDBID: 4XBM, Subunit B, Seq Identity:48%, EGF-like domain

AA: 755-785, PDBID: 1PFX, Subunit L, Seq Identity:51%, EGF-like domain

AA: 793-823, PDBID: 4XBM, Subunit B, Seq Identity:55%, EGF-like domain

AA: 831-861, PDBID: 1EDM, Subunit B, Seq Identity:51%, EGF-like domain

UniProt annotation for JAG2_HUMAN » Protein jagged-2
FUNCTION: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).

TISSUE SPECIFICITY: Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney.

UniProt features for JAG2_HUMAN » Protein jagged-2
SIGNAL 1 23 Potential.
CHAIN 24 1238 Protein jagged-2.
DOMAIN 196 240 DSL.
DOMAIN 241 274 EGF-like 1.
DOMAIN 275 305 EGF-like 2; atypical.
DOMAIN 307 345 EGF-like 3.
DOMAIN 347 383 EGF-like 4.
DOMAIN 385 421 EGF-like 5; calcium-binding (Potential).
DOMAIN 423 459 EGF-like 6; calcium-binding (Potential).
DOMAIN 461 496 EGF-like 7; calcium-binding (Potential).
DOMAIN 498 534 EGF-like 8.
DOMAIN 536 572 EGF-like 9.
DOMAIN 574 634 EGF-like 10; atypical.
DOMAIN 636 672 EGF-like 11; calcium-binding (Potential).
DOMAIN 674 710 EGF-like 12; calcium-binding (Potential).
DOMAIN 712 748 EGF-like 13.
DOMAIN 751 787 EGF-like 14.
DOMAIN 789 825 EGF-like 15; calcium-binding (Potential).
DOMAIN 827 863 EGF-like 16; calcium-binding (Potential).
DOMAIN 870 944 VWFC.
DISULFID 198 207 By similarity.
DISULFID 211 223 By similarity.
DISULFID 231 240 By similarity.
DISULFID 245 256 By similarity.
DISULFID 249 262 By similarity.
DISULFID 264 273 By similarity.
DISULFID 276 287 By similarity.
DISULFID 282 293 By similarity.
DISULFID 295 304 By similarity.
DISULFID 311 323 By similarity.
DISULFID 317 333 By similarity.
DISULFID 335 344 By similarity.
DISULFID 351 362 By similarity.
DISULFID 356 371 By similarity.
DISULFID 373 382 By similarity.
DISULFID 389 400 By similarity.
DISULFID 394 409 By similarity.
DISULFID 411 420 By similarity.
DISULFID 427 438 By similarity.
DISULFID 432 447 By similarity.
DISULFID 449 458 By similarity.
DISULFID 465 475 By similarity.
DISULFID 469 484 By similarity.
DISULFID 486 495 By similarity.
DISULFID 502 513 By similarity.
DISULFID 507 522 By similarity.
DISULFID 524 533 By similarity.
DISULFID 540 551 By similarity.
DISULFID 545 560 By similarity.
DISULFID 562 571 By similarity.
DISULFID 589 612 Potential.
DISULFID 606 622 Potential.
DISULFID 624 633 By similarity.
DISULFID 640 651 By similarity.
DISULFID 645 660 By similarity.
DISULFID 662 671 By similarity.
DISULFID 678 689 By similarity.
DISULFID 683 698 By similarity.
DISULFID 700 709 By similarity.
DISULFID 716 727 By similarity.
DISULFID 721 736 By similarity.
DISULFID 738 747 By similarity.
DISULFID 755 766 By similarity.
DISULFID 760 775 By similarity.
DISULFID 777 786 By similarity.
DISULFID 793 804 By similarity.
DISULFID 798 813 By similarity.
DISULFID 815 824 By similarity.
DISULFID 831 842 By similarity.
DISULFID 836 851 By similarity.
DISULFID 853 862 By similarity.
Amino Acid Sequence for JAG2_HUMAN » Protein jagged-2
MRAQGRGRLP RRLLLLLALW VQAARPMGYF ELQLSALRNV NGELLSGACC DGDGRTTRAG GCGHDECDTY VRVCLKEYQA KVTPTGPCSY GHGATPVLGG NSFYLPPAGA AGDRARARAR AGGDQDPGLV VIPFQFAWPR SFTLIVEAWD WDNDTTPNEE LLIERVSHAG MINPEDRWKS LHFSGHVAHL ELQIRVRCDE NYYSATCNKF CRPRNDFFGH YTCDQYGNKA CMDGWMGKEC KEAVCKQGCN LLHGGCTVPG ECRCSYGWQG RFCDECVPYP GCVHGSCVEP WQCNCETNWG GLLCDKDLNY CGSHHPCTNG GTCINAEPDQ YRCTCPDGYS GRNCEKAEHA CTSNPCANGG SCHEVPSGFE CHCPSGWSGP TCALDIDECA SNPCAAGGTC VDQVDGFECI CPEQWVGATC QLDANECEGK PCLNAFSCKN LIGGYYCDCI PGWKGINCHI NVNDCRGQCQ HGGTCKDLVN GYQCVCPRGF GGRHCELERD ECASSPCHSG GLCEDLADGF HCHCPQGFSG PLCEVDVDLC EPSPCRNGAR CYNLEGDYYC ACPDDFGGKN CSVPREPCPG GACRVIDGCG SDAGPGMPGT AASGVCGPHG RCVSQPGGNF SCICDSGFTG TYCHENIDDC LGQPCRNGGT CIDEVDAFRC FCPSGWEGEL CDTNPNDCLP DPCHSRGRCY DLVNDFYCAC DDGWKGKTCH SREFQCDAYT CSNGGTCYDS GDTFRCACPP GWKGSTCAVA KNSSCLPNPC VNGGTCVGSG ASFSCICRDG WEGRTCTHNT NDCNPLPCYN GGICVDGVNW FRCECAPGFA GPDCRINIDE CQSSPCAYGA TCVDEINGYR CSCPPGRAGP RCQEVIGFGR SCWSRGTPFP HGSSWVEDCN SCRCLDGRRD CSKVWCGWKP CLLAGQPEAL SAQCPLGQRC LEKAPGQCLR PPCEAWGECG AEEPPSTPCL PRSGHLDNNC ARLTLHFNRD HVPQGTTVGA ICSGIRSLPA TRAVARDRLL VLLCDRASSG ASAVEVAVSF SPARDLPDSS LIQGAAHAIV AAITQRGNSS LLLAVTEVKV ETVVTGGSST GLLVPVLCGA FSVLWLACVV LCVWWTRKRR KERERSRLPR EESANNQWAP LNPIRNPIER PGGHKDVLYQ CKNFTPPPRR ADEALPGPAG HAAVREDEED EDLGRGEEDS LEAEKFLSHK FTKDPGRSPG RPAHWASGPK VDNRAVRSIN EARYAGKE