JAG1_HUMAN » Protein jagged-1

JAG1_HUMAN » Protein jagged-1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
JAG1_HUMAN » Protein jagged-1 » Jagged1; hJ1;
Hydrophobic Thickness 31.6 ± 2.2 Å
Tilt Angle 1 ± 0°
ΔGtransfer -29.2 kcal/mol
ΔGfold -12.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 1068-1093 (1065-1097)
Pathways

Notch signaling pathway (KEGG)

Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor (Reactome)

Signal Transduction (Reactome)

TNF signaling pathway (KEGG)

PDB 2vj2 (185-335), 2kb9 (252-295), 4cbz (32-335), 4cc0 (32-335), 4cc1 (32-335)
OPM 2vj2
Complexes none
Interactions

ADA17, Complex: JAG1:ADA17, PubMed

CALX, Complex: JAG1:CALX, PubMed

MCP, Complex: MCP:JAG1

MFNG, Complex: MFNG:JAG1, PubMed

NOTC1, Complex: NOTC1:JAG1, PubMed

NOTC2, Complex: JAG1:NOTC2, PubMed

NOTC3, Complex: NOTC3:JAG1, PubMed

Domains

AA: 32-107, PDBID: 4CBZ, Subunit B, Seq Identity:100%, N terminus of Notch ligand

AA: 167-229, PDBID: 2VJ2, Subunit A, Seq Identity:100%, Delta serrate ligand

AA: 300-332, PDBID: 2VJ2, Subunit A, Seq Identity:100%, EGF-like domain

AA: 340-370, PDBID: 1EDM, Subunit B, Seq Identity:48%, EGF-like domain

AA: 378-408, PDBID: 4XBM, Subunit B, Seq Identity:51%, EGF-like domain

AA: 412-450, PDBID: 1TOZ, Subunit A, Seq Identity:40%, Calcium-binding EGF domain

AA: 450-483, PDBID: 4XBM, Subunit B, Seq Identity:41%, EGF-like domain

AA: 491-521, PDBID: 1TOZ, Subunit A, Seq Identity:62%, EGF-like domain

AA: 529-559, PDBID: 1EDM, Subunit B, Seq Identity:54%, EGF-like domain

AA: 633-663, PDBID: 1EDM, Subunit B, Seq Identity:63%, EGF-like domain

AA: 671-701, PDBID: 1EDM, Subunit B, Seq Identity:51%, EGF-like domain

AA: 748-777, PDBID: 1PFX, Subunit L, Seq Identity:51%, EGF-like domain

AA: 786-816, PDBID: 4XBM, Subunit B, Seq Identity:55%, EGF-like domain

AA: 829-849, PDBID: 2YGQ, Subunit A, Seq Identity:52%, Human growth factor-like EGF

UniProt annotation for JAG1_HUMAN » Protein jagged-1
FUNCTION: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).

SUBUNIT: Interacts with NOTCH2 and NOTCH3 (By similarity). Interacts with NOTCH1 (in the presence of calcium ions).

TISSUE SPECIFICITY: Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.

DEVELOPMENTAL STAGE: Expressed in 32-52 days embryos in the distal cardiac outflow tract and pulmonary artery, major arteries, portal vein, optic vesicle, otocyst, branchial arches, metanephros, pancreas, mesocardium, around the major bronchial branches, and in the neural tube.

DOMAIN: The second EGF-like domain is atypical.

DISEASE: Alagille syndrome 1 (ALGS1) OMIM: A form of Alagille syndrome, an autosomal dominant multisystem disorder. It is clinically defined by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems. mutations affecting the gene represented in this entry.

DISEASE: Tetralogy of Fallot (TOF) OMIM: A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis. mutations affecting the gene represented in this entry.

UniProt features for JAG1_HUMAN » Protein jagged-1
SIGNAL 1 33 Potential.
CHAIN 34 1218 Protein jagged-1.
DOMAIN 185 229 DSL.
DOMAIN 230 263 EGF-like 1.
DOMAIN 264 294 EGF-like 2; atypical.
DOMAIN 296 334 EGF-like 3.
DOMAIN 336 372 EGF-like 4.
DOMAIN 374 410 EGF-like 5; calcium-binding (Potential).
DOMAIN 412 448 EGF-like 6; calcium-binding (Potential).
DOMAIN 450 485 EGF-like 7; calcium-binding (Potential).
DOMAIN 487 523 EGF-like 8; calcium-binding (Potential).
DOMAIN 525 561 EGF-like 9.
DOMAIN 586 627 EGF-like 10.
DOMAIN 629 665 EGF-like 11; calcium-binding (Potential).
DOMAIN 667 703 EGF-like 12; calcium-binding (Potential).
DOMAIN 705 741 EGF-like 13.
DOMAIN 744 780 EGF-like 14.
DOMAIN 782 818 EGF-like 15; calcium-binding (Potential).
DOMAIN 820 856 EGF-like 16; calcium-binding (Potential).
REGION 199 207 Important for interaction with NOTCH1.
DISULFID 187 196
DISULFID 200 212
DISULFID 220 229
DISULFID 234 245
DISULFID 238 251
DISULFID 253 262
DISULFID 265 276
DISULFID 271 282
DISULFID 284 293
DISULFID 300 312
DISULFID 306 322
DISULFID 324 333
DISULFID 340 351 By similarity.
DISULFID 345 360 By similarity.
DISULFID 362 371 By similarity.
DISULFID 378 389 By similarity.
DISULFID 383 398 By similarity.
DISULFID 400 409 By similarity.
DISULFID 416 427 By similarity.
DISULFID 421 436 By similarity.
DISULFID 438 447 By similarity.
DISULFID 454 464 By similarity.
DISULFID 458 473 By similarity.
DISULFID 475 484 By similarity.
DISULFID 491 502 By similarity.
DISULFID 496 511 By similarity.
DISULFID 513 522 By similarity.
DISULFID 529 540 By similarity.
DISULFID 534 549 By similarity.
DISULFID 551 560 By similarity.
DISULFID 578 605 By similarity.
DISULFID 599 615 By similarity.
DISULFID 617 626 By similarity.
DISULFID 633 644 By similarity.
DISULFID 638 653 By similarity.
DISULFID 655 664 By similarity.
DISULFID 671 682 By similarity.
DISULFID 676 691 By similarity.
DISULFID 693 702 By similarity.
DISULFID 709 720 By similarity.
DISULFID 714 729 By similarity.
DISULFID 731 740 By similarity.
DISULFID 748 759 By similarity.
DISULFID 753 768 By similarity.
DISULFID 770 779 By similarity.
DISULFID 786 797 By similarity.
DISULFID 791 806 By similarity.
DISULFID 808 817 By similarity.
DISULFID 824 835 By similarity.
DISULFID 829 844 By similarity.
DISULFID 846 855 By similarity.
Amino Acid Sequence for JAG1_HUMAN » Protein jagged-1
MRSPRTRGRS GRPLSLLLAL LCALRAKVCG ASGQFELEIL SMQNVNGELQ NGNCCGGARN PGDRKCTRDE CDTYFKVCLK EYQSRVTAGG PCSFGSGSTP VIGGNTFNLK ASRGNDRNRI VLPFSFAWPR SYTLLVEAWD SSNDTVQPDS IIEKASHSGM INPSRQWQTL KQNTGVAHFE YQIRVTCDDY YYGFGCNKFC RPRDDFFGHY ACDQNGNKTC MEGWMGPECN RAICRQGCSP KHGSCKLPGD CRCQYGWQGL YCDKCIPHPG CVHGICNEPW QCLCETNWGG QLCDKDLNYC GTHQPCLNGG TCSNTGPDKY QCSCPEGYSG PNCEIAEHAC LSDPCHNRGS CKETSLGFEC ECSPGWTGPT CSTNIDDCSP NNCSHGGTCQ DLVNGFKCVC PPQWTGKTCQ LDANECEAKP CVNAKSCKNL IASYYCDCLP GWMGQNCDIN INDCLGQCQN DASCRDLVNG YRCICPPGYA GDHCERDIDE CASNPCLNGG HCQNEINRFQ CLCPTGFSGN LCQLDIDYCE PNPCQNGAQC YNRASDYFCK CPEDYEGKNC SHLKDHCRTT PCEVIDSCTV AMASNDTPEG VRYISSNVCG PHGKCKSQSG GKFTCDCNKG FTGTYCHENI NDCESNPCRN GGTCIDGVNS YKCICSDGWE GAYCETNIND CSQNPCHNGG TCRDLVNDFY CDCKNGWKGK TCHSRDSQCD EATCNNGGTC YDEGDAFKCM CPGGWEGTTC NIARNSSCLP NPCHNGGTCV VNGESFTCVC KEGWEGPICA QNTNDCSPHP CYNSGTCVDG DNWYRCECAP GFAGPDCRIN INECQSSPCA FGATCVDEIN GYRCVCPPGH SGAKCQEVSG RPCITMGSVI PDGAKWDDDC NTCQCLNGRI ACSKVWCGPR PCLLHKGHSE CPSGQSCIPI LDDQCFVHPC TGVGECRSSS LQPVKTKCTS DSYYQDNCAN ITFTFNKEMM SPGLTTEHIC SELRNLNILK NVSAEYSIYI ACEPSPSANN EIHVAISAED IRDDGNPIKE ITDKIIDLVS KRDGNSSLIA AVAEVRVQRR PLKNRTDFLV PLLSSVLTVA WICCLVTAFY WCLRKRRKPG SHTHSASEDN TTNNVREQLN QIKNPIEKHG ANTVPIKDYE NKNSKMSKIR THNSEVEEDD MDKHQQKARF AKQPAYTLVD REEKPPNGTP TKHPNWTNKQ DNRDLESAQS LNRMEYIV