IZUM1_HUMAN » Izumo sperm-egg fusion protein 1

IZUM1_HUMAN » Izumo sperm-egg fusion protein 1
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Topology in Plasma membrane
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cytoplasmic side
IZUM1_HUMAN » Izumo sperm-egg fusion protein 1 » Oocyte binding/fusion factor;OBF; Sperm-specific protein izumo;
Hydrophobic Thickness 35.6 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -43.5 kcal/mol
ΔGfold -15.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 289-314 (284-317)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 21-166, Izumo sperm-egg fusion, Ig domain-associated

AA: 168-255, Izumo-like Immunoglobulin domain

UniProt annotation for IZUM1_HUMAN » Izumo sperm-egg fusion protein 1
FUNCTION: Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane "fusogen".

SUBUNIT: Monomer, homodimer and homooligomer. Interacts with IZUMO1R/JUNO (By similarity).

TISSUE SPECIFICITY: Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction.

MISCELLANEOUS: Izumo is the name of a Japanese shrine to marriage.

UniProt features for IZUM1_HUMAN » Izumo sperm-egg fusion protein 1
SIGNAL 1 21 Potential.
CHAIN 22 350 Izumo sperm-egg fusion protein 1.
DOMAIN 167 251 Ig-like C2-type.
DISULFID 182 233 By similarity.
Amino Acid Sequence for IZUM1_HUMAN » Izumo sperm-egg fusion protein 1
MGPHFTLLCA ALAGCLLPAE GCVICDPSVV LALKSLEKDY LPGHLDAKHH KAMMERVENA VKDFQELSLN EDAYMGVVDE ATLQKGSWSL LKDLKRITDS DVKGDLFVKE LFWMLHLQKE TFATYVARFQ KEAYCPNKCG VMLQTLIWCK NCKKEVHACR KSYDCGERNV EVPQMEDMIL DCELNWHQAS EGLTDYSFYR VWGNNTETLV SKGKEATLTK PMVGPEDAGS YRCELGSVNS SPATIINFHV TVLPKMIKEE KPSPNIVTPG EATTESSISL QPLQPEKMLA SRLLGLLICG SLALITGLTF AIFRRRKVID FIKSSLFGLG SGVAEQTQVP KEKATDSRQQ