ITM2C_HUMAN » Integral membrane protein 2C

ITM2C_HUMAN » Integral membrane protein 2C
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITM2C_HUMAN » Integral membrane protein 2C » Cerebral protein 14;Transmembrane protein BRI3;
Hydrophobic Thickness 34.4 ± 1.0 Å
Tilt Angle 20 ± 3°
ΔGtransfer -25.6 kcal/mol
ΔGfold -16.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 58-83 (58-83)
Pathways none
PDB none
OPM none
Complexes none
Interactions

BACE1, Complex: BACE1:ITM2C, PubMed

FURIN, Complex: ITM2C:FURIN, PubMed

RYK, Complex: ITM2C:RYK, PubMed

Domains

AA: 138-229, PDBID: 2YAD, Subunit F, Seq Identity:18%, BRICHOS domain

UniProt annotation for ITM2C_HUMAN » Integral membrane protein 2C
FUNCTION: Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).

SUBUNIT: Interacts with BACE1. Interacts with APP. Interacts with STMN2.

TISSUE SPECIFICITY: High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs.

UniProt features for ITM2C_HUMAN » Integral membrane protein 2C
CHAIN 1 267 Integral membrane protein 2C.
PEPTIDE 243 267 CT-BRI3.
DOMAIN 136 230 BRICHOS.
SITE 242 243 Cleavage; by furin.
Amino Acid Sequence for ITM2C_HUMAN » Integral membrane protein 2C
MVKISFQPAV AGIKGDKADK ASASAPAPAS ATEILLTPAR EEQPPQHRSK RGGSVGGVCY LSMGMVVLLM GLVFASVYIY RYFFLAQLAR DNFFRCGVLY EDSLSSQVRT QMELEEDVKI YLDENYERIN VPVPQFGGGD PADIIHDFQR GLTAYHDISL DKCYVIELNT TIVLPPRNFW ELLMNVKRGT YLPQTYIIQE EMVVTEHVSD KEALGSFIYH LCNGKDTYRL RRRATRRRIN KRGAKNCNAI RHFENTFVVE TLICGVV