ITB8_HUMAN » Integrin beta-8

ITB8_HUMAN » Integrin beta-8
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITB8_HUMAN » Integrin beta-8 »
Hydrophobic Thickness 34.4 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -29.5 kcal/mol
ΔGfold -20.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 682-704 (680-706)
Pathways

Arrhythmogenic right ventricular cardiomyopathy (KEGG)

Cell adhesion molecules (KEGG)

Dilated cardiomyopathy (KEGG)

ECM-receptor interaction (KEGG)

Extracellular matrix organization (Reactome)

Focal adhesion (KEGG)

Hypertrophic cardiomyopathy (KEGG)

PI3K-Akt signaling pathway (KEGG)

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

ITAV, Complex: ITB8:ITAV:MMP14:TGFB1, PubMed

Domains

AA: 45-95, PDBID: 3VI3, Subunit B, Seq Identity:47%, Integrin plexin domain

AA: 142-388, PDBID: 4UM8, Subunit D, Seq Identity:48%, Integrin beta chain VWA domain

AA: 553-583, PDBID: 1JV2, Subunit B, Seq Identity:51%, EGF-like domain

UniProt annotation for ITB8_HUMAN » Integrin beta-8
FUNCTION: Integrin alpha-V/beta-8 is a receptor for fibronectin.

SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-8 associates with alpha-V.

TISSUE SPECIFICITY: Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.

UniProt features for ITB8_HUMAN » Integrin beta-8
SIGNAL 1 42 Potential.
CHAIN 43 769 Integrin beta-8.
DOMAIN 146 384 VWFA.
REPEAT 471 510 I.
REPEAT 511 552 II.
REPEAT 553 592 III.
REPEAT 593 629 IV.
REGION 471 629 Cysteine-rich tandem repeats.
DISULFID 47 469 By similarity.
DISULFID 55 65 By similarity.
DISULFID 58 94 By similarity.
DISULFID 68 83 By similarity.
DISULFID 211 218 By similarity.
DISULFID 266 307 By similarity.
DISULFID 407 419 By similarity.
DISULFID 467 471 By similarity.
DISULFID 494 499 By similarity.
DISULFID 526 531 By similarity.
DISULFID 528 561 By similarity.
DISULFID 533 546 By similarity.
DISULFID 567 572 By similarity.
DISULFID 574 583 By similarity.
DISULFID 585 593 By similarity.
DISULFID 607 612 By similarity.
DISULFID 609 657 By similarity.
DISULFID 614 624 By similarity.
DISULFID 627 630 By similarity.
DISULFID 634 643 By similarity.
Amino Acid Sequence for ITB8_HUMAN » Integrin beta-8
MCGSALAFFT AAFVCLQNDR RGPASFLWAA WVFSLVLGLG QGEDNRCASS NAASCARCLA LGPECGWCVQ EDFISGGSRS ERCDIVSNLI SKGCSVDSIE YPSVHVIIPT ENEINTQVTP GEVSIQLRPG AEANFMLKVH PLKKYPVDLY YLVDVSASMH NNIEKLNSVG NDLSRKMAFF SRDFRLGFGS YVDKTVSPYI SIHPERIHNQ CSDYNLDCMP PHGYIHVLSL TENITEFEKA VHRQKISGNI DTPEGGFDAM LQAAVCESHI GWRKEAKRLL LVMTDQTSHL ALDSKLAGIV VPNDGNCHLK NNVYVKSTTM EHPSLGQLSE KLIDNNINVI FAVQGKQFHW YKDLLPLLPG TIAGEIESKA ANLNNLVVEA YQKLISEVKV QVENQVQGIY FNITAICPDG SRKPGMEGCR NVTSNDEVLF NVTVTMKKCD VTGGKNYAII KPIGFNETAK IHIHRNCSCQ CEDNRGPKGK CVDETFLDSK CFQCDENKCH FDEDQFSSES CKSHKDQPVC SGRGVCVCGK CSCHKIKLGK VYGKYCEKDD FSCPYHHGNL CAGHGECEAG RCQCFSGWEG DRCQCPSAAA QHCVNSKGQV CSGRGTCVCG RCECTDPRSI GRFCEHCPTC YTACKENWNC MQCLHPHNLS QAILDQCKTS CALMEQQHYV DQTSECFSSP SYLRIFFIIF IVTFLIGLLK VLIIRQVILQ WNSNKIKSSS DYRVSASKKD KLILQSVCTR AVTYRREKPE EIKMDISKLN AHETFRCNF