ITB7_HUMAN » Integrin beta-7

ITB7_HUMAN » Integrin beta-7
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITB7_HUMAN » Integrin beta-7 » Gut homing receptor beta subunit;
Hydrophobic Thickness 28.4 ± 2.6 Å
Tilt Angle 2 ± 1°
ΔGtransfer -32.5 kcal/mol
ΔGfold -14.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 724-753 (721-755)
Pathways

Arrhythmogenic right ventricular cardiomyopathy (KEGG)

Cell adhesion molecules (KEGG)

Dilated cardiomyopathy (KEGG)

ECM-receptor interaction (KEGG)

Focal adhesion (KEGG)

Hypertrophic cardiomyopathy (KEGG)

Immune System (Reactome)

Intestinal immune network for IgA production (KEGG)

PI3K-Akt signaling pathway (KEGG)

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

Transcriptional misregulation in cancer (KEGG)

PDB 3v4p (B/D=20-512), 3v4v (B/D=20-512), 2brq (C/D=768-798)
OPM none
Complexes

ITB7:ITA4_HUMAN

Interactions

CADH1, Complex: CADH1:ITB7, PubMed

ITA4, Complex: ITB7:ITA4, PDBID: 3v4p, PubMed

ITAE, Complex: ITAE:ITB7, PubMed

MADCA, Complex: ITB7:MADCA, PubMed

VCAM1, Complex: VCAM1:ITB7, PubMed

Domains

AA: 43-92, PDBID: 1YUK, Subunit A, Seq Identity:43%, Integrin plexin domain

AA: 147-393, PDBID: 3V4P, Subunit B, Seq Identity:100%, Integrin beta chain VWA domain

AA: 605-635, PDBID: 1JV2, Subunit B, Seq Identity:54%, EGF-like domain

AA: 747-791, PDBID: 2BRQ, Subunit C, Seq Identity:100%, Integrin beta cytoplasmic domain

UniProt annotation for ITB7_HUMAN » Integrin beta-7
FUNCTION: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Integrin alpha-4/beta-7 interacts with MADCAM1, VCAM, fibronectin, and may also interact with HIV-1 gp120.

TISSUE SPECIFICITY: Expressed in a variety of leukocyte lines.

INDUCTION: Integrin alpha-E/beta-7 is induced by TGFB1.

DOMAIN: Domain I contains three cation-binding sites: the ligand- integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.

UniProt features for ITB7_HUMAN » Integrin beta-7
SIGNAL 1 19
CHAIN 20 798 Integrin beta-7.
DOMAIN 150 389 VWFA.
REPEAT 478 526 I.
REPEAT 527 565 II.
REPEAT 566 604 III.
REPEAT 605 640 IV.
REGION 478 640 Cysteine-rich tandem repeats.
DISULFID 45 476 By similarity.
DISULFID 51 61 By similarity.
DISULFID 54 91 By similarity.
DISULFID 64 80 By similarity.
DISULFID 216 223 By similarity.
DISULFID 271 311 By similarity.
DISULFID 412 428 By similarity.
DISULFID 448 688 By similarity.
DISULFID 474 478 By similarity.
DISULFID 488 500 By similarity.
DISULFID 497 537 By similarity.
DISULFID 502 511 By similarity.
DISULFID 513 527 By similarity.
DISULFID 543 548 By similarity.
DISULFID 545 574 By similarity.
DISULFID 550 559 By similarity.
DISULFID 561 566 By similarity.
DISULFID 580 585 By similarity.
DISULFID 582 613 By similarity.
DISULFID 587 596 By similarity.
DISULFID 598 605 By similarity.
DISULFID 619 624 By similarity.
DISULFID 621 666 By similarity.
DISULFID 626 635 By similarity.
DISULFID 638 641 By similarity.
DISULFID 645 654 By similarity.
Amino Acid Sequence for ITB7_HUMAN » Integrin beta-7
MVALPMVLVL LLVLSRGESE LDAKIPSTGD ATEWRNPHLS MLGSCQPAPS CQKCILSHPS CAWCKQLNFT ASGEAEARRC ARREELLARG CPLEELEEPR GQQEVLQDQP LSQGARGEGA TQLAPQRVRV TLRPGEPQQL QVRFLRAEGY PVDLYYLMDL SYSMKDDLER VRQLGHALLV RLQEVTHSVR IGFGSFVDKT VLPFVSTVPS KLRHPCPTRL ERCQSPFSFH HVLSLTGDAQ AFEREVGRQS VSGNLDSPEG GFDAILQAAL CQEQIGWRNV SRLLVFTSDD TFHTAGDGKL GGIFMPSDGH CHLDSNGLYS RSTEFDYPSV GQVAQALSAA NIQPIFAVTS AALPVYQELS KLIPKSAVGE LSEDSSNVVQ LIMDAYNSLS STVTLEHSSL PPGVHISYES QCEGPEKREG KAEDRGQCNH VRINQTVTFW VSLQATHCLP EPHLLRLRAL GFSEELIVEL HTLCDCNCSD TQPQAPHCSD GQGHLQCGVC SCAPGRLGRL CECSVAELSS PDLESGCRAP NGTGPLCSGK GHCQCGRCSC SGQSSGHLCE CDDASCERHE GILCGGFGRC QCGVCHCHAN RTGRACECSG DMDSCISPEG GLCSGHGRCK CNRCQCLDGY YGALCDQCPG CKTPCERHRD CAECGAFRTG PLATNCSTAC AHTNVTLALA PILDDGWCKE RTLDNQLFFF LVEDDARGTV VLRVRPQEKG ADHTQAIVLG CVGGIVAVGL GLVLAYRLSV EIYDRREYSR FEKEQQQLNW KQDSNPLYKS AITTTINPRF QEADSPTL