ITB6_HUMAN » Integrin beta-6

ITB6_HUMAN » Integrin beta-6
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITB6_HUMAN » Integrin beta-6 »
Hydrophobic Thickness 34.0 ± 3.2 Å
Tilt Angle 38 ± 2°
ΔGtransfer -32.1 kcal/mol
ΔGfold -21.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 708-736 (708-740)
Pathways

Arrhythmogenic right ventricular cardiomyopathy (KEGG)

Dilated cardiomyopathy (KEGG)

ECM-receptor interaction (KEGG)

Extracellular matrix organization (Reactome)

Focal adhesion (KEGG)

Hypertrophic cardiomyopathy (KEGG)

PI3K-Akt signaling pathway (KEGG)

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

PDB 4um8 (B/D=1-788), 4um9 (B/D=1-788)
OPM none
Complexes

ITAV:ITB6_HUMAN

Interactions

ITA5, Complex: ITA5:ITB6:TENA, PubMed

ITAV, Complex: ITAV:ITB6, PDBID: 4um8, PubMed

Domains

AA: 22-71, PDBID: 4UM8, Subunit B, Seq Identity:100%, Integrin plexin domain

AA: 128-375, PDBID: 4UM8, Subunit D, Seq Identity:100%, Integrin beta chain VWA domain

AA: 544-574, PDBID: 1JV2, Subunit B, Seq Identity:54%, EGF-like domain

AA: 583-614, PDBID: 1JV2, Subunit B, Seq Identity:65%, EGF-like domain

AA: 624-707, PDBID: 1JV2, Subunit B, Seq Identity:27%, Integrin beta tail domain

AA: 731-775, PDBID: 1KUP, Subunit B, Seq Identity:65%, Integrin beta cytoplasmic domain

UniProt annotation for ITB6_HUMAN » Integrin beta-6
FUNCTION: Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.

SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-6 associates with alpha-V. Interacts with FLNB. Interacts with HAX1. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein, coxsackievirus A9, coxsackievirus B1 capsid proteins and acts as a receptor for these viruses.

UniProt features for ITB6_HUMAN » Integrin beta-6
SIGNAL 1 21 Potential.
CHAIN 22 788 Integrin beta-6.
DOMAIN 131 371 VWFA.
REPEAT 456 501 I.
REPEAT 502 543 II.
REPEAT 544 582 III.
REPEAT 583 619 IV.
REGION 456 619 Cysteine-rich tandem repeats.
REGION 731 758 Interaction with HAX1.
DISULFID 23 454 By similarity.
DISULFID 31 41 By similarity.
DISULFID 34 70 By similarity.
DISULFID 44 59 By similarity.
DISULFID 197 204 By similarity.
DISULFID 252 293 By similarity.
DISULFID 394 406 By similarity.
DISULFID 426 670 By similarity.
DISULFID 452 456 By similarity.
DISULFID 467 479 By similarity.
DISULFID 476 511 By similarity.
DISULFID 481 490 By similarity.
DISULFID 492 502 By similarity.
DISULFID 517 522 By similarity.
DISULFID 519 552 By similarity.
DISULFID 524 537 By similarity.
DISULFID 539 544 By similarity.
DISULFID 558 563 By similarity.
DISULFID 560 591 By similarity.
DISULFID 565 574 By similarity.
DISULFID 576 583 By similarity.
DISULFID 597 602 By similarity.
DISULFID 599 645 By similarity.
DISULFID 604 614 By similarity.
DISULFID 617 620 By similarity.
DISULFID 624 633 By similarity.
DISULFID 630 702 By similarity.
DISULFID 649 678 By similarity.
Amino Acid Sequence for ITB6_HUMAN » Integrin beta-6
MGIELLCLFF LFLGRNDHVQ GGCALGGAET CEDCLLIGPQ CAWCAQENFT HPSGVGERCD TPANLLAKGC QLNFIENPVS QVEILKNKPL SVGRQKNSSD IVQIAPQSLI LKLRPGGAQT LQVHVRQTED YPVDLYYLMD LSASMDDDLN TIKELGSRLS KEMSKLTSNF RLGFGSFVEK PVSPFVKTTP EEIANPCSSI PYFCLPTFGF KHILPLTNDA ERFNEIVKNQ KISANIDTPE GGFDAIMQAA VCKEKIGWRN DSLHLLVFVS DADSHFGMDS KLAGIVIPND GLCHLDSKNE YSMSTVLEYP TIGQLIDKLV QNNVLLIFAV TQEQVHLYEN YAKLIPGATV GLLQKDSGNI LQLIISAYEE LRSEVELEVL GDTEGLNLSF TAICNNGTLF QHQKKCSHMK VGDTASFSVT VNIPHCERRS RHIIIKPVGL GDALELLVSP ECNCDCQKEV EVNSSKCHHG NGSFQCGVCA CHPGHMGPRC ECGEDMLSTD SCKEAPDHPS CSGRGDCYCG QCICHLSPYG NIYGPYCQCD NFSCVRHKGL LCGGNGDCDC GECVCRSGWT GEYCNCTTST DSCVSEDGVL CSGRGDCVCG KCVCTNPGAS GPTCERCPTC GDPCNSKRSC IECHLSAAGQ AREECVDKCK LAGATISEEE DFSKDGSVSC SLQGENECLI TFLITTDNEG KTIIHSINEK DCPKPPNIPM IMLGVSLAIL LIGVVLLCIW KLLVSFHDRK EVAKFEAERS KAKWQTGTNP LYRGSTSTFK NVTYKHREKQ KVDLSTDC