ITB5_HUMAN » Integrin beta-5

ITB5_HUMAN » Integrin beta-5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITB5_HUMAN » Integrin beta-5 »
Hydrophobic Thickness 33.6 ± 4.2 Å
Tilt Angle 43 ± 0°
ΔGtransfer -31.1 kcal/mol
ΔGfold -24.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 720-748 (720-752)
Pathways

Arrhythmogenic right ventricular cardiomyopathy (KEGG)

Dilated cardiomyopathy (KEGG)

ECM-receptor interaction (KEGG)

Extracellular matrix organization (Reactome)

Focal adhesion (KEGG)

Hypertrophic cardiomyopathy (KEGG)

Immune System (Reactome)

Muscle contraction (Reactome)

Phagosome (KEGG)

PI3K-Akt signaling pathway (KEGG)

Proteoglycans in cancer (KEGG)

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

DCC, Complex: DCC:ITB5, PubMed

EPHA2, Complex: EPHA2:ITB5

FDFT, Complex: FDFT:ITB5, PubMed

ITA3, Complex: ITB5:ITA3, PubMed

ITA5, Complex: ITB5:ITA5, PubMed

ITAV, Complex: ITAV:ITB5:CYR61, PubMed

ITB1, Complex: ITB1:KPCE:ITB5, PubMed

LEPR, Complex: LEPR:ITB5, PubMed

MERTK, Complex: MERTK:ITB5

Domains

AA: 26-76, PDBID: 1TYE, Subunit F, Seq Identity:47%, Integrin plexin domain

AA: 133-382, PDBID: 1JV2, Subunit B, Seq Identity:66%, Integrin beta chain VWA domain

AA: 635-719, PDBID: 1JV2, Subunit B, Seq Identity:41%, Integrin beta tail domain

AA: 743-788, PDBID: 1KUP, Subunit B, Seq Identity:57%, Integrin beta cytoplasmic domain

UniProt annotation for ITB5_HUMAN » Integrin beta-5
FUNCTION: Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.

SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-5 (ITGB5) associates with alpha-V (ITGAV). Interacts with MYO10 (PubMed). Interacts with DAB2. Integrin ITGAV:ITGB5 interacts with FBLN5 (via N-terminus) (By similarity).

UniProt features for ITB5_HUMAN » Integrin beta-5
SIGNAL 1 23 Potential.
CHAIN 24 799 Integrin beta-5.
DOMAIN 27 76 PSI.
DOMAIN 136 378 VWFA.
REPEAT 465 512 I.
REPEAT 513 554 II.
REPEAT 555 593 III.
REPEAT 594 630 IV.
REGION 465 630 Cysteine-rich tandem repeats.
DISULFID 28 463 By similarity.
DISULFID 36 46 By similarity.
DISULFID 39 75 By similarity.
DISULFID 49 64 By similarity.
DISULFID 202 211 By similarity.
DISULFID 259 300 By similarity.
DISULFID 401 413 By similarity.
DISULFID 433 682 By similarity.
DISULFID 461 465 By similarity.
DISULFID 476 487 By similarity.
DISULFID 484 522 By similarity.
DISULFID 489 498 By similarity.
DISULFID 500 513 By similarity.
DISULFID 528 533 By similarity.
DISULFID 530 563 By similarity.
DISULFID 535 548 By similarity.
DISULFID 550 555 By similarity.
DISULFID 569 574 By similarity.
DISULFID 571 602 By similarity.
DISULFID 576 585 By similarity.
DISULFID 587 594 By similarity.
DISULFID 608 613 By similarity.
DISULFID 610 657 By similarity.
DISULFID 615 625 By similarity.
DISULFID 628 631 By similarity.
DISULFID 635 644 By similarity.
DISULFID 641 714 By similarity.
DISULFID 661 690 By similarity.
Amino Acid Sequence for ITB5_HUMAN » Integrin beta-5
MPRAPAPLYA CLLGLCALLP RLAGLNICTS GSATSCEECL LIHPKCAWCS KEDFGSPRSI TSRCDLRANL VKNGCGGEIE SPASSFHVLR SLPLSSKGSG SAGWDVIQMT PQEIAVNLRP GDKTTFQLQV RQVEDYPVDL YYLMDLSLSM KDDLDNIRSL GTKLAEEMRK LTSNFRLGFG SFVDKDISPF SYTAPRYQTN PCIGYKLFPN CVPSFGFRHL LPLTDRVDSF NEEVRKQRVS RNRDAPEGGF DAVLQAAVCK EKIGWRKDAL HLLVFTTDDV PHIALDGKLG GLVQPHDGQC HLNEANEYTA SNQMDYPSLA LLGEKLAENN INLIFAVTKN HYMLYKNFTA LIPGTTVEIL DGDSKNIIQL IINAYNSIRS KVELSVWDQP EDLNLFFTAT CQDGVSYPGQ RKCEGLKIGD TASFEVSLEA RSCPSRHTEH VFALRPVGFR DSLEVGVTYN CTCGCSVGLE PNSARCNGSG TYVCGLCECS PGYLGTRCEC QDGENQSVYQ NLCREAEGKP LCSGRGDCSC NQCSCFESEF GKIYGPFCEC DNFSCARNKG VLCSGHGECH CGECKCHAGY IGDNCNCSTD ISTCRGRDGQ ICSERGHCLC GQCQCTEPGA FGEMCEKCPT CPDACSTKRD CVECLLLHSG KPDNQTCHSL CRDEVITWVD TIVKDDQEAV LCFYKTAKDC VMMFTYVELP SGKSNLTVLR EPECGNTPNA MTILLAVVGS ILLVGLALLA IWKLLVTIHD RREFAKFQSE RSRARYEMAS NPLYRKPIST HTVDFTFNKF NKSYNGTVD