ITB2_HUMAN » Integrin beta-2

ITB2_HUMAN » Integrin beta-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITB2_HUMAN » Integrin beta-2 » Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta;Complement receptor C3 subunit beta;
Hydrophobic Thickness 34.4 ± 3.4 Å
Tilt Angle 34 ± 4°
ΔGtransfer -24.2 kcal/mol
ΔGfold -19.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 701-730 (699-732)
Pathways

Amoebiasis (KEGG)

Cell adhesion molecules (KEGG)

Hemostasis (Reactome)

Hippo signaling pathway (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Legionellosis (KEGG)

Leishmaniasis (KEGG)

Leukocyte transendothelial migration (KEGG)

Malaria (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

Pertussis (KEGG)

Phagosome (KEGG)

Regulation of actin cytoskeleton (KEGG)

Rheumatoid arthritis (KEGG)

Signal Transduction (Reactome)

Staphylococcus aureus infection (KEGG)

Tuberculosis (KEGG)

Viral myocarditis (KEGG)

PDB 2p26 (23-535), 1l3y (535-574), 2p28 (A=23-122, B=362-574), 1yuk (A=23-125, B=365-482), 3k6s (B/D/F/H=23-699), 3k71 (B/D/F/H=23-699), 3k72 (B/D=23-699), 4neh (B=23-695), 4nen (B=23-696), 2v7d (P/Q/R/S=755-764), 2jf1 (T=735-769)
OPM none
Complexes

ITB2:ITAX_HUMAN

Interactions

CD226, Complex: CD226:ITB2, PubMed

EGFR, Complex: EGFR:ITB2, PubMed

FCER2, Complex: ITB2:FCER2, PubMed

FUT4, Complex: FUT4:ITB2, PubMed

ICAM1, Complex: ITB2:ICAM1, PubMed

ICAM2, Complex: ITB2:ICAM2, PubMed

ICAM3, Complex: ITB2:ICAM3, PubMed

ICAM4, Complex: ITB2:ICAM4, PubMed

ICAM5, Complex: ICAM5:ITB2, PubMed

ITAD, Complex: ITB2:ITAD, PubMed

ITAL, Complex: ITAL:ITB2, PubMed

ITAM, Complex: ITB2:ITAM, PubMed

ITAX, Complex: ITB2:ITAX, PDBID: 3k6s, PubMed

JAM3, Complex: ITAM:ITB2:JAM3

Domains

AA: 23-74, PDBID: 1YUK, Subunit A, Seq Identity:100%, Integrin plexin domain

AA: 122-367, PDBID: 1YUK, Subunit B, Seq Identity:100%, Integrin beta chain VWA domain

AA: 622-700, PDBID: 3K6S, Subunit H, Seq Identity:100%, Integrin beta tail domain

AA: 724-767, PDBID: 2JF1, Subunit T, Seq Identity:100%, Integrin beta cytoplasmic domain

UniProt annotation for ITB2_HUMAN » Integrin beta-2
FUNCTION: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.

SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with FGR (By similarity). Interacts with COPS5 and RANBP9.

DISEASE: Leukocyte adhesion deficiency 1 (LAD1) OMIM: LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions. mutations affecting the gene represented in this entry.

UniProt features for ITB2_HUMAN » Integrin beta-2
SIGNAL 1 22
CHAIN 23 769 Integrin beta-2.
DOMAIN 124 363 VWFA.
REPEAT 449 496 I.
REPEAT 497 540 II.
REPEAT 541 581 III.
REPEAT 582 617 IV.
REGION 449 617 Cysteine-rich tandem repeats.
MOTIF 397 399 Cell attachment site (Potential).
DISULFID 25 43
DISULFID 33 447
DISULFID 36 62
DISULFID 46 73
DISULFID 191 198
DISULFID 246 286
DISULFID 386 400
DISULFID 420 445
DISULFID 449 467
DISULFID 459 470
DISULFID 472 481
DISULFID 483 514
DISULFID 497 512
DISULFID 506 517
DISULFID 519 534
DISULFID 536 559
DISULFID 541 557
DISULFID 549 562
DISULFID 564 573
DISULFID 575 598
DISULFID 582 596
DISULFID 590 601
DISULFID 603 612
DISULFID 615 618
DISULFID 622 662
DISULFID 628 647
DISULFID 631 643
DISULFID 670 695
Amino Acid Sequence for ITB2_HUMAN » Integrin beta-2
MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN FTGPGDPDSI RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP QKVTLYLRPG QAAAFNVTFR RAKGYPIDLY YLMDLSYSML DDLRNVKKLG GDLLRALNEI TESGRIGFGS FVDKTVLPFV NTHPDKLRNP CPNKEKECQP PFAFRHVLKL TNNSNQFQTE VGKQLISGNL DAPEGGLDAM MQVAACPEEI GWRNVTRLLV FATDDGFHFA GDGKLGAILT PNDGRCHLED NLYKRSNEFD YPSVGQLAHK LAENNIQPIF AVTSRMVKTY EKLTEIIPKS AVGELSEDSS NVVQLIKNAY NKLSSRVFLD HNALPDTLKV TYDSFCSNGV THRNQPRGDC DGVQINVPIT FQVKVTATEC IQEQSFVIRA LGFTDIVTVQ VLPQCECRCR DQSRDRSLCH GKGFLECGIC RCDTGYIGKN CECQTQGRSS QELEGSCRKD NNSIICSGLG DCVCGQCLCH TSDVPGKLIY GQYCECDTIN CERYNGQVCG GPGRGLCFCG KCRCHPGFEG SACQCERTTE GCLNPRRVEC SGRGRCRCNV CECHSGYQLP LCQECPGCPS PCGKYISCAE CLKFEKGPFG KNCSAACPGL QLSNNPVKGR TCKERDSEGC WVAYTLEQQD GMDRYLIYVD ESRECVAGPN IAAIVGGTVA GIVLIGILLL VIWKALIHLS DLREYRRFEK EKLKSQWNND NPLFKSATTT VMNPKFAES