ITAX_HUMAN » Integrin alpha-X

ITAX_HUMAN » Integrin alpha-X
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITAX_HUMAN » Integrin alpha-X » CD11 antigen-like family member C;Leu M5;Leukocyte adhesion glycoprotein p150,95 alpha chain;Leukocyte adhesion receptor p150,95;
Hydrophobic Thickness 32.4 ± 2.2 Å
Tilt Angle 6 ± 6°
ΔGtransfer -19.2 kcal/mol
ΔGfold -14.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 1113-1134 (1112-1137)
Pathways

Hemostasis (Reactome)

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

Tuberculosis (KEGG)

PDB 2luv (1129-1163), 1n3y (147-338), 3k6s (A/C/E/G=20-1103), 3k71 (A/C/E/G=20-1103), 3k72 (A/C=20-1103), 4neh (A=20-1101), 4nen (A=20-1101)
OPM 2luv
Complexes

ITB2:ITAX_HUMAN

Interactions

FCER2, Complex: ITAX:FCER2, PubMed

ITB2, Complex: ITB2:ITAX, PDBID: 3k6s, PubMed

JAM3, Complex: ITAX:JAM3, PubMed

TNR3, Complex: TNR3:ITAX, PubMed

Domains

AA: 151-328, PDBID: 1N3Y, Subunit A, Seq Identity:100%, von Willebrand factor type A domain

AA: 458-495, PDBID: 3K6S, Subunit E, Seq Identity:100%, FG-GAP repeat

AA: 521-556, PDBID: 3K6S, Subunit E, Seq Identity:100%, FG-GAP repeat

AA: 615-1015, PDBID: 3K6S, Subunit C, Seq Identity:100%, Integrin alpha

AA: 1129-1143, PDBID: 2LUV, Subunit A, Seq Identity:100%, Integrin alpha cytoplasmic region

UniProt annotation for ITAX_HUMAN » Integrin alpha-X
FUNCTION: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2.

TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes.

DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

UniProt features for ITAX_HUMAN » Integrin alpha-X
SIGNAL 1 19
CHAIN 20 1163 Integrin alpha-X.
REPEAT 23 78 FG-GAP 1.
REPEAT 79 138 FG-GAP 2.
DOMAIN 165 339 VWFA.
REPEAT 340 391 FG-GAP 3.
REPEAT 392 445 FG-GAP 4.
REPEAT 446 504 FG-GAP 5.
REPEAT 507 565 FG-GAP 6.
REPEAT 570 630 FG-GAP 7.
MOTIF 1131 1135 GFFKR motif.
DISULFID 69 76
DISULFID 108 126
DISULFID 116 145
DISULFID 495 506
DISULFID 639 722
DISULFID 655 712
DISULFID 771 777
DISULFID 848 863
DISULFID 998 1022
DISULFID 1027 1032
Amino Acid Sequence for ITAX_HUMAN » Integrin alpha-X
MTRTRAALLL FTALATSLGF NLDTEELTAF RVDSAGFGDS VVQYANSWVV VGAPQKITAA NQTGGLYQCG YSTGACEPIG LQVPPEAVNM SLGLSLASTT SPSQLLACGP TVHHECGRNM YLTGLCFLLG PTQLTQRLPV SRQECPRQEQ DIVFLIDGSG SISSRNFATM MNFVRAVISQ FQRPSTQFSL MQFSNKFQTH FTFEEFRRSS NPLSLLASVH QLQGFTYTAT AIQNVVHRLF HASYGARRDA AKILIVITDG KKEGDSLDYK DVIPMADAAG IIRYAIGVGL AFQNRNSWKE LNDIASKPSQ EHIFKVEDFD ALKDIQNQLK EKIFAIEGTE TTSSSSFELE MAQEGFSAVF TPDGPVLGAV GSFTWSGGAF LYPPNMSPTF INMSQENVDM RDSYLGYSTE LALWKGVQSL VLGAPRYQHT GKAVIFTQVS RQWRMKAEVT GTQIGSYFGA SLCSVDVDSD GSTDLVLIGA PHYYEQTRGG QVSVCPLPRG WRRWWCDAVL YGEQGHPWGR FGAALTVLGD VNGDKLTDVV IGAPGEEENR GAVYLFHGVL GPSISPSHSQ RIAGSQLSSR LQYFGQALSG GQDLTQDGLV DLAVGARGQV LLLRTRPVLW VGVSMQFIPA EIPRSAFECR EQVVSEQTLV QSNICLYIDK RSKNLLGSRD LQSSVTLDLA LDPGRLSPRA TFQETKNRSL SRVRVLGLKA HCENFNLLLP SCVEDSVTPI TLRLNFTLVG KPLLAFRNLR PMLAADAQRY FTASLPFEKN CGADHICQDN LGISFSFPGL KSLLVGSNLE LNAEVMVWND GEDSYGTTIT FSHPAGLSYR YVAEGQKQGQ LRSLHLTCDS APVGSQGTWS TSCRINHLIF RGGAQITFLA TFDVSPKAVL GDRLLLTANV SSENNTPRTS KTTFQLELPV KYAVYTVVSS HEQFTKYLNF SESEEKESHV AMHRYQVNNL GQRDLPVSIN FWVPVELNQE AVWMDVEVSH PQNPSLRCSS EKIAPPASDF LAHIQKNPVL DCSIAGCLRF RCDVPSFSVQ EELDFTLKGN LSFGWVRQIL QKKVSVVSVA EITFDTSVYS QLPGQEAFMR AQTTTVLEKY KVHNPTPLIV GSSIGGLLLL ALITAVLYKV GFFKRQYKEM MEEANGQIAP ENGTQTPSPP SEK