ITAV_HUMAN » Integrin alpha-V

ITAV_HUMAN » Integrin alpha-V
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITAV_HUMAN » Integrin alpha-V » Vitronectin receptor subunit alpha;
Hydrophobic Thickness 35.6 ± 3.4 Å
Tilt Angle 35 ± 7°
ΔGtransfer -33.7 kcal/mol
ΔGfold -29.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 991-1018 (991-1018)
Pathways

Arrhythmogenic right ventricular cardiomyopathy (KEGG)

Cell adhesion molecules (KEGG)

Developmental Biology (Reactome)

Dilated cardiomyopathy (KEGG)

ECM-receptor interaction (KEGG)

Extracellular matrix organization (Reactome)

Focal adhesion (KEGG)

Hemostasis (Reactome)

Hypertrophic cardiomyopathy (KEGG)

Immune System (Reactome)

Pathways in cancer (KEGG)

Phagosome (KEGG)

PI3K-Akt signaling pathway (KEGG)

Proteoglycans in cancer (KEGG)

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

Small cell lung cancer (KEGG)

PDB 4um9 (A/C=31-625), 4um8 (A/C=31-625), 1jv2 (A=31-987), 1u8c (A=31-987), 1m1x (A=31-987), 1l5g (A=31-987), 4g1e (A=31-989), 4mmx (A=31-989), 4mmy (A=31-989), 4mmz (A=31-989), 4g1m (A=31-989), 4o02 (A=31-992), 3ije (A=31-997)
OPM 3ije
Complexes

ITAV:ITB6_HUMAN

ITB3:FINC:ITAV_HUMAN

ITB3:ITAV_HUMAN

Interactions

4F2, Complex: 4F2:ITB3:ITAV

ADA15, Complex: ITAV:ADA15:ITB3, PubMed

ADA23, Complex: ADA23:ITAV:ITB3, PubMed

ADAM9, Complex: ITB5:ADAM9:ITAV, PubMed

AUP1, Complex: ITAV:AUP1, PubMed

CSF1R, Complex: ITAV:CSF1R, PubMed

EGFR, Complex: ITAV:ITB3:EGFR

EPHA2, Complex: EPHA2:ITAV

FCER2, Complex: ITB3:CD47:ITAV:FCER2, PubMed

ICAM4, Complex: ICAM4:ITAV, PubMed

ICAM4, Complex: ITAV:ICAM4:ITB5, PubMed

ITB1, Complex: ITB1:ITAV:NOV, PubMed

ITB3, Complex: ITAV:ITB3, PDBID: 1jv2

ITB5, Complex: ITAV:ITB5:UPAR, PubMed

ITB6, Complex: ITAV:ITB6, PDBID: 4um8, PubMed

ITB8, Complex: ITB8:ITAV:MMP14:TGFB1, PubMed

JAM1, Complex: ITB3:ITAV:JAM1, PubMed

L1CAM, Complex: ITAV:L1CAM, PubMed

MMP14, Complex: ITAV:MMP14, PubMed

PGFRA, Complex: PGFRA:ITAV, PubMed

PTPRZ, Complex: PTPRZ:ITAV

THY1, Complex: THY1:ITAV, PubMed

Domains

AA: 252-286, PDBID: 1JV2, Subunit A, Seq Identity:100%, FG-GAP repeat

AA: 306-348, PDBID: 1JV2, Subunit A, Seq Identity:100%, FG-GAP repeat

AA: 370-406, PDBID: 1JV2, Subunit A, Seq Identity:100%, FG-GAP repeat

AA: 467-914, PDBID: 1JV2, Subunit A, Seq Identity:100%, Integrin alpha

AA: 1017-1031, PDBID: 1DPK, Subunit A, Seq Identity:64%, Integrin alpha cytoplasmic region

UniProt annotation for ITAV_HUMAN » Integrin alpha-V
FUNCTION: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi"s sarcoma lesions.

SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. lpha-V (ITGAV) associates with either beta-1 (ITGB1), beta-3 (ITGB3), beta-5 (ITGB5), beta-6 (ITGB6) or beta-8 (ITGB8). Interacts with CIB1 (PubMed). Interacts with RAB25 (PubMed). Integrins ITGAV:ITGB3 and ITGAV:ITGB5 interact with FBLN5 (via N-terminus) (By similarity). Interacts with HIV-1 Tat (PubMed). Alpha-V/beta-6 binds to foot- and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus (By similarity). Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses. Alpha-V/beta-3 interacts with herpes virus 8/HHV-8 glycoprotein B and acts as a receptor for the virus.

UniProt features for ITAV_HUMAN » Integrin alpha-V
SIGNAL 1 30
CHAIN 31 1048 Integrin alpha-V.
CHAIN 31 889 Integrin alpha-V heavy chain.
CHAIN 891 1048 Integrin alpha-V light chain.
REPEAT 32 98 FG-GAP 1.
REPEAT 109 170 FG-GAP 2.
REPEAT 173 225 FG-GAP 3.
REPEAT 237 295 FG-GAP 4.
REPEAT 296 357 FG-GAP 5.
REPEAT 358 415 FG-GAP 6.
REPEAT 419 482 FG-GAP 7.
MOTIF 1019 1023 GFFKR motif.
DISULFID 89 97
DISULFID 138 158
DISULFID 172 185
DISULFID 491 502
DISULFID 508 565
DISULFID 626 632
DISULFID 698 711
DISULFID 852 914 Interchain (between heavy and light chains).
DISULFID 904 909
Amino Acid Sequence for ITAV_HUMAN » Integrin alpha-V
MAFPPRRRLR LGPRGLPLLL SGLLLPLCRA FNLDVDSPAE YSGPEGSYFG FAVDFFVPSA SSRMFLLVGA PKANTTQPGI VEGGQVLKCD WSSTRRCQPI EFDATGNRDY AKDDPLEFKS HQWFGASVRS KQDKILACAP LYHWRTEMKQ EREPVGTCFL QDGTKTVEYA PCRSQDIDAD GQGFCQGGFS IDFTKADRVL LGGPGSFYWQ GQLISDQVAE IVSKYDPNVY SIKYNNQLAT RTAQAIFDDS YLGYSVAVGD FNGDGIDDFV SGVPRAARTL GMVYIYDGKN MSSLYNFTGE QMAAYFGFSV AATDINGDDY ADVFIGAPLF MDRGSDGKLQ EVGQVSVSLQ RASGDFQTTK LNGFEVFARF GSAIAPLGDL DQDGFNDIAI AAPYGGEDKK GIVYIFNGRS TGLNAVPSQI LEGQWAARSM PPSFGYSMKG ATDIDKNGYP DLIVGAFGVD RAILYRARPV ITVNAGLEVY PSILNQDNKT CSLPGTALKV SCFNVRFCLK ADGKGVLPRK LNFQVELLLD KLKQKGAIRR ALFLYSRSPS HSKNMTISRG GLMQCEELIA YLRDESEFRD KLTPITIFME YRLDYRTAAD TTGLQPILNQ FTPANISRQA HILLDCGEDN VCKPKLEVSV DSDQKKIYIG DDNPLTLIVK AQNQGEGAYE AELIVSIPLQ ADFIGVVRNN EALARLSCAF KTENQTRQVV CDLGNPMKAG TQLLAGLRFS VHQQSEMDTS VKFDLQIQSS NLFDKVSPVV SHKVDLAVLA AVEIRGVSSP DHVFLPIPNW EHKENPETEE DVGPVVQHIY ELRNNGPSSF SKAMLHLQWP YKYNNNTLLY ILHYDIDGPM NCTSDMEINP LRIKISSLQT TEKNDTVAGQ GERDHLITKR DLALSEGDIH TLGCGVAQCL KIVCQVGRLD RGKSAILYVK SLLWTETFMN KENQNHSYSL KSSASFNVIE FPYKNLPIED ITNSTLVTTN VTWGIQPAPM PVPVWVIILA VLAGLLLLAV LVFVMYRMGF FKRVRPPQEE QEREQLQPHE NGEGNSET