ITAM_HUMAN » Integrin alpha-M

ITAM_HUMAN » Integrin alpha-M
Magnify ITAM_HUMAN » Integrin alpha-MEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITAM_HUMAN » Integrin alpha-M » CD11 antigen-like family member B;CR-3 alpha chain;Cell surface glycoprotein MAC-1 subunit alpha;Leukocyte adhesion receptor MO1;Neutrophil adherence receptor;
Hydrophobic Thickness 32.6 ± 2.1 Å
Tilt Angle 7 ± 1°
ΔGtransfer -18.9 kcal/mol
ΔGfold -14.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 1113-1134 (1112-1137)
Pathways

Amoebiasis (KEGG)

Cell adhesion molecules (KEGG)

Hematopoietic cell lineage (KEGG)

Hemostasis (Reactome)

Immune System (Reactome)

Legionellosis (KEGG)

Leishmaniasis (KEGG)

Leukocyte transendothelial migration (KEGG)

Pertussis (KEGG)

Phagosome (KEGG)

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

Staphylococcus aureus infection (KEGG)

Transcriptional misregulation in cancer (KEGG)

Tuberculosis (KEGG)

PDB 1bho (1/2=149-337), 1bhq (1/2=149-337), 1idn (1/2=149-337), 2lkj (1129-1152), 2lke (1129-1152), 1m1u (139-331), 1ido (143-331), 1jlm (143-334), 1mf7 (144-333), 1na5 (144-335), 1n9z (144-335), 4m76 (B=143-337), 3q3g (E/G/I/L=148-337), 3qa3 (E/G/I/L=148-337)
OPM 2lke
Complexes none
Interactions

AUP1, Complex: ITAM:AUP1, PubMed

CD209, Complex: CD209:ITAM, PubMed

CLC4M, Complex: CLC4M:ITAM, PubMed

GP1BA, Complex: ITAM:GP1BA, PubMed

ICAM1, Complex: ITAM:ICAM1, PubMed

ICAM2, Complex: ICAM2:ITAM, PubMed

ICAM4, Complex: ITAM:ICAM4, PubMed

ITB2, Complex: ITB2:CD63:ITAM, PubMed

ITB2, Complex: ITB2:ITAM, PubMed

JAM3, Complex: ITAM:JAM3, PubMed

THY1, Complex: THY1:ITAM, PubMed

TNR3, Complex: ITAM:TNR3, PubMed

Domains

AA: 150-327, PDBID: 1BHO, Subunit 1, Seq Identity:100%, von Willebrand factor type A domain

AA: 520-555, PDBID: 3K6S, Subunit E, Seq Identity:95%, FG-GAP repeat

AA: 614-1005, PDBID: 3K6S, Subunit C, Seq Identity:52%, Integrin alpha

AA: 1129-1143, PDBID: 2LKE, Subunit A, Seq Identity:100%, Integrin alpha cytoplasmic region

UniProt annotation for ITAM_HUMAN » Integrin alpha-M
FUNCTION: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3.

TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes.

DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

DISEASE: Systemic lupus erythematosus 6 (SLEB6) OMIM: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

UniProt features for ITAM_HUMAN » Integrin alpha-M
SIGNAL 1 16
CHAIN 17 1152 Integrin alpha-M.
REPEAT 18 75 FG-GAP 1.
REPEAT 76 135 FG-GAP 2.
DOMAIN 150 328 VWFA.
REPEAT 339 390 FG-GAP 3.
REPEAT 391 444 FG-GAP 4.
REPEAT 445 503 FG-GAP 5.
REPEAT 506 564 FG-GAP 6.
REPEAT 569 629 FG-GAP 7.
MOTIF 1131 1135 GFFKR motif.
DISULFID 66 73 By similarity.
DISULFID 105 123 By similarity.
DISULFID 654 711 By similarity.
DISULFID 770 776 By similarity.
DISULFID 847 864 By similarity.
DISULFID 998 1022 By similarity.
DISULFID 1027 1032 By similarity.
Amino Acid Sequence for ITAM_HUMAN » Integrin alpha-M
MALRVLLLTA LTLCHGFNLD TENAMTFQEN ARGFGQSVVQ LQGSRVVVGA PQEIVAANQR GSLYQCDYST GSCEPIRLQV PVEAVNMSLG LSLAATTSPP QLLACGPTVH QTCSENTYVK GLCFLFGSNL RQQPQKFPEA LRGCPQEDSD IAFLIDGSGS IIPHDFRRMK EFVSTVMEQL KKSKTLFSLM QYSEEFRIHF TFKEFQNNPN PRSLVKPITQ LLGRTHTATG IRKVVRELFN ITNGARKNAF KILVVITDGE KFGDPLGYED VIPEADREGV IRYVIGVGDA FRSEKSRQEL NTIASKPPRD HVFQVNNFEA LKTIQNQLRE KIFAIEGTQT GSSSSFEHEM SQEGFSAAIT SNGPLLSTVG SYDWAGGVFL YTSKEKSTFI NMTRVDSDMN DAYLGYAAAI ILRNRVQSLV LGAPRYQHIG LVAMFRQNTG MWESNANVKG TQIGAYFGAS LCSVDVDSNG STDLVLIGAP HYYEQTRGGQ VSVCPLPRGR ARWQCDAVLY GEQGQPWGRF GAALTVLGDV NGDKLTDVAI GAPGEEDNRG AVYLFHGTSG SGISPSHSQR IAGSKLSPRL QYFGQSLSGG QDLTMDGLVD LTVGAQGHVL LLRSQPVLRV KAIMEFNPRE VARNVFECND QVVKGKEAGE VRVCLHVQKS TRDRLREGQI QSVVTYDLAL DSGRPHSRAV FNETKNSTRR QTQVLGLTQT CETLKLQLPN CIEDPVSPIV LRLNFSLVGT PLSAFGNLRP VLAEDAQRLF TALFPFEKNC GNDNICQDDL SITFSFMSLD CLVVGGPREF NVTVTVRNDG EDSYRTQVTF FFPLDLSYRK VSTLQNQRSQ RSWRLACESA SSTEVSGALK STSCSINHPI FPENSEVTFN ITFDVDSKAS LGNKLLLKAN VTSENNMPRT NKTEFQLELP VKYAVYMVVT SHGVSTKYLN FTASENTSRV MQHQYQVSNL GQRSLPISLV FLVPVRLNQT VIWDRPQVTF SENLSSTCHT KERLPSHSDF LAELRKAPVV NCSIAVCQRI QCDIPFFGIQ EEFNATLKGN LSFDWYIKTS HNHLLIVSTA EILFNDSVFT LLPGQGAFVR SQTETKVEPF EVPNPLPLIV GSSVGGLLLL ALITAALYKL GFFKRQYKDM MSEGGPPGAE PQ