ITAL_HUMAN » Integrin alpha-L

ITAL_HUMAN » Integrin alpha-L
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITAL_HUMAN » Integrin alpha-L » CD11 antigen-like family member A;Leukocyte adhesion glycoprotein LFA-1 alpha chain;LFA-1A; Leukocyte function-associated molecule 1 alpha chain;
Hydrophobic Thickness 33.6 ± 2.0 Å
Tilt Angle 35 ± 3°
ΔGtransfer -28.8 kcal/mol
ΔGfold -22.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 1089-1117 (1084-1119)
Pathways

Cell adhesion molecules (KEGG)

Epstein-Barr virus infection (KEGG)

Hemostasis (Reactome)

HTLV-I infection (KEGG)

Immune System (Reactome)

Leukocyte transendothelial migration (KEGG)

Malaria (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

Regulation of actin cytoskeleton (KEGG)

Rheumatoid arthritis (KEGG)

Signal Transduction (Reactome)

Staphylococcus aureus infection (KEGG)

Viral myocarditis (KEGG)

PDB 2m3e (1082-1128), 2k8o (1113-1170), 1zon (150-336), 1rd4 (150-336), 1dgq (152-336), 1xuo (152-336), 1xdg (152-336), 1xdd (152-336), 1mqa (153-331), 1mq9 (153-331), 1mjn (153-331), 3f74 (153-332), 3f78 (153-332), 1cqp (153-334), 2o7n (154-332), 3m6f (154-332), 2ica (154-332), 1zop (A/B=150-336), 1zoo (A/B=150-336), 1lfa (A/B=150-336), 3e2m (A/B=152-334), 3hi6 (A/B=153-332), 4ixd (A=152-336), 1t0p (A=153-326), 3bn3 (A=154-332), 3bqm (B/C=153-334), 3bqn (B/C=153-334), 3tcx (B/D...=154-332), 1mq8 (B/D=155-331), 3eoa (I/J=153-333), 3eob (I/J=153-333)
OPM 2m3e, 2k8o
Complexes

ICAM1:ITAL_HUMAN

ICAM3:ITAL_HUMAN

ICAM5:ITAL_HUMAN

Interactions

ICAM1, Complex: ICAM1:ITAL, PDBID: 1ij4, PubMed

ICAM3, Complex: ICAM3:ITAL, PDBID: 1t0p, PubMed

ICAM4, Complex: ITAL:ICAM4:ITB2

ICAM5, Complex: ICAM5:ITAL, PDBID: 3bn3

ITB2, Complex: ITAL:ITB2:GBLP

ITB2, Complex: ITAL:ITB2, PubMed

JAM1, Complex: ITAL:JAM1, PubMed

PTPRC, Complex: PTPRC:ITAL, PubMed

TNR3, Complex: ITAL:TNR3, PubMed

Domains

AA: 156-326, PDBID: 1CQP, Subunit B, Seq Identity:100%, von Willebrand factor type A domain

AA: 521-554, PDBID: 3V4P, Subunit C, Seq Identity:54%, FG-GAP repeat

AA: 612-1002, PDBID: 3K6S, Subunit C, Seq Identity:30%, Integrin alpha

AA: 1113-1127, PDBID: 2K8O, Subunit A, Seq Identity:100%, Integrin alpha cytoplasmic region

UniProt annotation for ITAL_HUMAN » Integrin alpha-L
FUNCTION: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.

SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.

TISSUE SPECIFICITY: Leukocytes.

DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

UniProt features for ITAL_HUMAN » Integrin alpha-L
SIGNAL 1 25
CHAIN 26 1170 Integrin alpha-L.
REPEAT 31 82 FG-GAP 1.
REPEAT 83 141 FG-GAP 2.
DOMAIN 156 327 VWFA.
REPEAT 338 389 FG-GAP 3.
REPEAT 390 445 FG-GAP 4.
REPEAT 446 506 FG-GAP 5.
REPEAT 507 563 FG-GAP 6.
REPEAT 567 627 FG-GAP 7.
MOTIF 1115 1119 GFFKR motif.
DISULFID 73 80 By similarity.
DISULFID 111 129 By similarity.
DISULFID 653 707 By similarity.
DISULFID 771 777 By similarity.
DISULFID 845 861 By similarity.
DISULFID 998 1013 By similarity.
DISULFID 1021 1052 By similarity.
Amino Acid Sequence for ITAL_HUMAN » Integrin alpha-L
MKDSCITVMA MALLSGFFFF APASSYNLDV RGARSFSPPR AGRHFGYRVL QVGNGVIVGA PGEGNSTGSL YQCQSGTGHC LPVTLRGSNY TSKYLGMTLA TDPTDGSILA CDPGLSRTCD QNTYLSGLCY LFRQNLQGPM LQGRPGFQEC IKGNVDLVFL FDGSMSLQPD EFQKILDFMK DVMKKLSNTS YQFAAVQFST SYKTEFDFSD YVKRKDPDAL LKHVKHMLLL TNTFGAINYV ATEVFREELG ARPDATKVLI IITDGEATDS GNIDAAKDII RYIIGIGKHF QTKESQETLH KFASKPASEF VKILDTFEKL KDLFTELQKK IYVIEGTSKQ DLTSFNMELS SSGISADLSR GHAVVGAVGA KDWAGGFLDL KADLQDDTFI GNEPLTPEVR AGYLGYTVTW LPSRQKTSLL ASGAPRYQHM GRVLLFQEPQ GGGHWSQVQT IHGTQIGSYF GGELCGVDVD QDGETELLLI GAPLFYGEQR GGRVFIYQRR QLGFEEVSEL QGDPGYPLGR FGEAITALTD INGDGLVDVA VGAPLEEQGA VYIFNGRHGG LSPQPSQRIE GTQVLSGIQW FGRSIHGVKD LEGDGLADVA VGAESQMIVL SSRPVVDMVT LMSFSPAEIP VHEVECSYST SNKMKEGVNI TICFQIKSLI PQFQGRLVAN LTYTLQLDGH RTRRRGLFPG GRHELRRNIA VTTSMSCTDF SFHFPVCVQD LISPINVSLN FSLWEEEGTP RDQRAQGKDI PPILRPSLHS ETWEIPFEKN CGEDKKCEAN LRVSFSPARS RALRLTAFAS LSVELSLSNL EEDAYWVQLD LHFPPGLSFR KVEMLKPHSQ IPVSCEELPE ESRLLSRALS CNVSSPIFKA GHSVALQMMF NTLVNSSWGD SVELHANVTC NNEDSDLLED NSATTIIPIL YPINILIQDQ EDSTLYVSFT PKGPKIHQVK HMYQVRIQPS IHDHNIPTLE AVVGVPQPPS EGPITHQWSV QMEPPVPCHY EDLERLPDAA EPCLPGALFR CPVVFRQEIL VQVIGTLELV GEIEASSMFS LCSSLSISFN SSKHFHLYGS NASLAQVVMK VDVVYEKQML YLYVLSGIGG LLLLLLIFIV LYKVGFFKRN LKEKMEAGRG VPNGIPAEDS EQLASGQEAG DPGCLKPLHE KDSESGGGKD