ITAE_HUMAN » Integrin alpha-E

ITAE_HUMAN » Integrin alpha-E
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITAE_HUMAN » Integrin alpha-E » HML-1 antigen;Integrin alpha-IEL;Mucosal lymphocyte 1 antigen;
Hydrophobic Thickness 32.0 ± 1.7 Å
Tilt Angle 6 ± 4°
ΔGtransfer -23.8 kcal/mol
ΔGfold -18.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 1132-1153 (1132-1155)
Pathways

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

CADH1, Complex: CADH1:ITB7:ITAE, PubMed

ITB7, Complex: ITAE:ITB7, PubMed

Domains

AA: 202-381, PDBID: 1BHO, Subunit 1, Seq Identity:33%, von Willebrand factor type A domain

AA: 514-551, PDBID: 3K6S, Subunit E, Seq Identity:50%, FG-GAP repeat

AA: 577-618, PDBID: 1JV2, Subunit A, Seq Identity:32%, FG-GAP repeat

AA: 676-965, PDBID: 1JV2, Subunit A, Seq Identity:25%, Integrin alpha

AA: 1148-1162, PDBID: 1DPK, Subunit A, Seq Identity:50%, Integrin alpha cytoplasmic region

UniProt annotation for ITAE_HUMAN » Integrin alpha-E
FUNCTION: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.

TISSUE SPECIFICITY: Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

INDUCTION: Integrin alpha-E/beta-7 is induced by TGFB1.

DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

UniProt features for ITAE_HUMAN » Integrin alpha-E
SIGNAL 1 18
CHAIN 19 1179 Integrin alpha-E.
CHAIN 19 177 Integrin alpha-E light chain.
CHAIN 179 1177 Integrin alpha-E heavy chain.
REPEAT 22 79 FG-GAP 1.
REPEAT 80 138 FG-GAP 2.
DOMAIN 200 389 VWFA.
REPEAT 390 442 FG-GAP 3.
REPEAT 447 501 FG-GAP 4.
REPEAT 502 560 FG-GAP 5.
REPEAT 563 627 FG-GAP 6.
REPEAT 631 691 FG-GAP 7.
REGION 145 199 X-domain (extra domain).
MOTIF 1150 1154 GFFKR motif.
DISULFID 70 79 By similarity.
DISULFID 126 159 By similarity.
DISULFID 706 762 By similarity.
DISULFID 823 829 By similarity.
DISULFID 893 907 By similarity.
DISULFID 1008 1033 By similarity.
DISULFID 1041 1057 By similarity.
Amino Acid Sequence for ITAE_HUMAN » Integrin alpha-E
MWLFHTLLCI ASLALLAAFN VDVARPWLTP KGGAPFVLSS LLHQDPSTNQ TWLLVTSPRT KRTPGPLHRC SLVQDEILCH PVEHVPIPKG RHRGVTVVRS HHGVLICIQV LVRRPHSLSS ELTGTCSLLG PDLRPQAQAN FFDLENLLDP DARVDTGDCY SNKEGGGEDD VNTARQRRAL EKEEEEDKEE EEDEEEEEAG TEIAIILDGS GSIDPPDFQR AKDFISNMMR NFYEKCFECN FALVQYGGVI QTEFDLRDSQ DVMASLARVQ NITQVGSVTK TASAMQHVLD SIFTSSHGSR RKASKVMVVL TDGGIFEDPL NLTTVINSPK MQGVERFAIG VGEEFKSART ARELNLIASD PDETHAFKVT NYMALDGLLS KLRYNIISME GTVGDALHYQ LAQIGFSAQI LDERQVLLGA VGAFDWSGGA LLYDTRSRRG RFLNQTAAAA ADAEAAQYSY LGYAVAVLHK TCSLSYIAGA PRYKHHGAVF ELQKEGREAS FLPVLEGEQM GSYFGSELCP VDIDMDGSTD FLLVAAPFYH VHGEEGRVYV YRLSEQDGSF SLARILSGHP GFTNARFGFA MAAMGDLSQD KLTDVAIGAP LEGFGADDGA SFGSVYIYNG HWDGLSASPS QRIRASTVAP GLQYFGMSMA GGFDISGDGL ADITVGTLGQ AVVFRSRPVV RLKVSMAFTP SALPIGFNGV VNVRLCFEIS SVTTASESGL REALLNFTLD VDVGKQRRRL QCSDVRSCLG CLREWSSGSQ LCEDLLLMPT EGELCEEDCF SNASVKVSYQ LQTPEGQTDH PQPILDRYTE PFAIFQLPYE KACKNKLFCV AELQLATTVS QQELVVGLTK ELTLNINLTN SGEDSYMTSM ALNYPRNLQL KRMQKPPSPN IQCDDPQPVA SVLIMNCRIG HPVLKRSSAH VSVVWQLEEN AFPNRTADIT VTVTNSNERR SLANETHTLQ FRHGFVAVLS KPSIMYVNTG QGLSHHKEFL FHVHGENLFG AEYQLQICVP TKLRGLQVVA VKKLTRTQAS TVCTWSQERA CAYSSVQHVE EWHSVSCVIA SDKENVTVAA EISWDHSEEL LKDVTELQIL GEISFNKSLY EGLNAENHRT KITVVFLKDE KYHSLPIIIK GSVGGLLVLI VILVILFKCG FFKRKYQQLN LESIRKAQLK SENLLEEEN