ITAD_HUMAN » Integrin alpha-D

ITAD_HUMAN » Integrin alpha-D
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITAD_HUMAN » Integrin alpha-D » ADB2;CD11 antigen-like family member D;Leukointegrin alpha D;
Hydrophobic Thickness 33.6 ± 7.0 Å
Tilt Angle 28 ± 4°
ΔGtransfer -20.6 kcal/mol
ΔGfold -17.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 1101-1126 (1095-1126)
Pathways

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

ICAM3, Complex: ITAD:ICAM3, PubMed

ITB2, Complex: ITB2:ITAD, PubMed

TNR3, Complex: TNR3:ITAD, PubMed

VCAM1, Complex: ITAD:VCAM1, PubMed

Domains

AA: 150-327, PDBID: 1BHO, Subunit 1, Seq Identity:57%, von Willebrand factor type A domain

AA: 457-494, PDBID: 3K6S, Subunit E, Seq Identity:97%, FG-GAP repeat

AA: 614-963, PDBID: 3K6S, Subunit C, Seq Identity:53%, Integrin alpha

AA: 1124-1138, PDBID: 2LUV, Subunit A, Seq Identity:70%, Integrin alpha cytoplasmic region

UniProt annotation for ITAD_HUMAN » Integrin alpha-D
FUNCTION: Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood- borne pathogens, particulate matter, and senescent erythrocytes from the blood.

SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-D associates with beta-2.

TISSUE SPECIFICITY: Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.

DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

UniProt features for ITAD_HUMAN » Integrin alpha-D
SIGNAL 1 17 Potential.
CHAIN 18 1161 Integrin alpha-D.
REPEAT 19 76 FG-GAP 1.
REPEAT 77 136 FG-GAP 2.
DOMAIN 150 332 VWFA.
REPEAT 339 390 FG-GAP 3.
REPEAT 391 444 FG-GAP 4.
REPEAT 445 502 FG-GAP 5.
REPEAT 506 564 FG-GAP 6.
REPEAT 569 629 FG-GAP 7.
MOTIF 1126 1130 GFFKR motif.
DISULFID 67 74 By similarity.
DISULFID 106 124 By similarity.
DISULFID 654 709 By similarity.
DISULFID 768 774 By similarity.
DISULFID 845 860 By similarity.
DISULFID 993 1017 By similarity.
DISULFID 1022 1027 By similarity.
Amino Acid Sequence for ITAD_HUMAN » Integrin alpha-D
MTFGTVLLLS VLASYHGFNL DVEEPTIFQE DAGGFGQSVV QFGGSRLVVG APLEVVAANQ TGRLYDCAAA TGMCQPIPLH IRPEAVNMSL GLTLAASTNG SRLLACGPTL HRVCGENSYS KGSCLLLGSR WEIIQTVPDA TPECPHQEMD IVFLIDGSGS IDQNDFNQMK GFVQAVMGQF EGTDTLFALM QYSNLLKIHF TFTQFRTSPS QQSLVDPIVQ LKGLTFTATG ILTVVTQLFH HKNGARKSAK KILIVITDGQ KYKDPLEYSD VIPQAEKAGI IRYAIGVGHA FQGPTARQEL NTISSAPPQD HVFKVDNFAA LGSIQKQLQE KIYAVEGTQS RASSSFQHEM SQEGFSTALT MDGLFLGAVG SFSWSGGAFL YPPNMSPTFI NMSQENVDMR DSYLGYSTEL ALWKGVQNLV LGAPRYQHTG KAVIFTQVSR QWRKKAEVTG TQIGSYFGAS LCSVDVDSDG STDLILIGAP HYYEQTRGGQ VSVCPLPRGQ RVQWQCDAVL RGEQGHPWGR FGAALTVLGD VNEDKLIDVA IGAPGEQENR GAVYLFHGAS ESGISPSHSQ RIASSQLSPR LQYFGQALSG GQDLTQDGLM DLAVGARGQV LLLRSLPVLK VGVAMRFSPV EVAKAVYRCW EEKPSALEAG DATVCLTIQK SSLDQLGDIQ SSVRFDLALD PGRLTSRAIF NETKNPTLTR RKTLGLGIHC ETLKLLLPDC VEDVVSPIIL HLNFSLVREP IPSPQNLRPV LAVGSQDLFT ASLPFEKNCG QDGLCEGDLG VTLSFSGLQT LTVGSSLELN VIVTVWNAGE DSYGTVVSLY YPAGLSHRRV SGAQKQPHQS ALRLACETVP TEDEGLRSSR CSVNHPIFHE GSNGTFIVTF DVSYKATLGD RMLMRASASS ENNKASSSKA TFQLELPVKY AVYTMISRQE ESTKYFNFAT SDEKKMKEAE HRYRVNNLSQ RDLAISINFW VPVLLNGVAV WDVVMEAPSQ SLPCVSERKP PQHSDFLTQI SRSPMLDCSI ADCLQFRCDV PSFSVQEELD FTLKGNLSFG WVRETLQKKV LVVSVAEITF DTSVYSQLPG QEAFMRAQME MVLEEDEVYN AIPIIMGSSV GALLLLALIT ATLYKLGFFK RHYKEMLEDK PEDTATFSGD DFSCVAPNVP LS