ITA9_HUMAN » Integrin alpha-9

ITA9_HUMAN » Integrin alpha-9
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITA9_HUMAN » Integrin alpha-9 » Integrin alpha-RLC;
Hydrophobic Thickness 37.2 ± 2.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -56.5 kcal/mol
ΔGfold -30.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 979-1008 (977-1011)
Pathways

Arrhythmogenic right ventricular cardiomyopathy (KEGG)

Cell adhesion molecules (KEGG)

Developmental Biology (Reactome)

Dilated cardiomyopathy (KEGG)

ECM-receptor interaction (KEGG)

Focal adhesion (KEGG)

Hypertrophic cardiomyopathy (KEGG)

PI3K-Akt signaling pathway (KEGG)

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

ADA12, Complex: ITB1:ITA9:ADA12, PubMed

ADA15, Complex: ITB1:ADA15:ITA9, PubMed

ADAM2, Complex: ADAM2:ITB1:ITA9, PubMed

ADAM8, Complex: ITB1:ADAM8:ITA9

ADAM9, Complex: ITB1:ITA9:ADAM9, PubMed

ITB1, Complex: ITB1:ITA9:VCAM1, PubMed

TNR1A, Complex: ITA9:TNR1A, PubMed

VCAM1, Complex: ITB1:VCAM1:ITA9, PubMed

Domains

AA: 304-340, PDBID: 3V4P, Subunit C, Seq Identity:62%, FG-GAP repeat

AA: 364-399, PDBID: 3V4P, Subunit C, Seq Identity:60%, FG-GAP repeat

AA: 459-909, PDBID: 3V4P, Subunit C, Seq Identity:38%, Integrin alpha

UniProt annotation for ITA9_HUMAN » Integrin alpha-9
FUNCTION: Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E- I-D-G-I-E-L in cytotactin.

SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-9 (ITGA9) associates with beta-1 (ITGB1). Integrin ITGA9:ITGB1 interacts with FBLN5 (via N-terminus).

TISSUE SPECIFICITY: In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers.

INDUCTION: Up-regulated in small cell lung cancers (SCLC).

UniProt features for ITA9_HUMAN » Integrin alpha-9
SIGNAL 1 29 Potential.
CHAIN 30 1035 Integrin alpha-9.
REPEAT 35 96 FG-GAP 1.
REPEAT 111 174 FG-GAP 2.
REPEAT 182 233 FG-GAP 3.
REPEAT 234 289 FG-GAP 4.
REPEAT 290 349 FG-GAP 5.
REPEAT 351 408 FG-GAP 6.
REPEAT 411 474 FG-GAP 7.
MOTIF 1005 1009 GFFKR motif.
SITE 565 566 Cleavage (Potential).
DISULFID 87 97 By similarity.
DISULFID 142 162 By similarity.
DISULFID 179 194 By similarity.
DISULFID 482 491 By similarity.
DISULFID 497 555 By similarity.
DISULFID 620 625 By similarity.
DISULFID 696 706 By similarity.
DISULFID 855 891 By similarity.
DISULFID 898 903 By similarity.
Amino Acid Sequence for ITA9_HUMAN » Integrin alpha-9
MGGPAAPRGA GRLRALLLAL VVAGIPAGAY NLDPQRPVHF QGPADSFFGY AVLEHFHDNT RWVLVGAPKA DSKYSPSVKS PGAVFKCRVH TNPDRRCTEL DMARGKNRGT SCGKTCREDR DDEWMGVSLA RQPKADGRVL ACAHRWKNIY YEADHILPHG FCYIIPSNLQ AKGRTLIPCY EEYKKKYGEE HGSCQAGIAG FFTEELVVMG APGSFYWAGT IKVLNLTDNT YLKLNDEVIM NRRYTYLGYA VTAGHFSHPS TIDVVGGAPQ DKGIGKVYIF RADRRSGTLI KIFQASGKKM GSYFGSSLCA VDLNGDGLSD LLVGAPMFSE IRDEGQVTVY INRGNGALEE QLALTGDGAY NAHFGESIAS LDDLDNDGFP DVAIGAPKED DFAGAVYIYH GDAGGIVPQY SMKLSGQKIN PVLRMFGQSI SGGIDMDGNG YPDVTVGAFM SDSVVLLRAR PVITVDVSIF LPGSINITAP QCHDGQQPVN CLNVTTCFSF HGKHVPGEIG LNYVLMADVA KKEKGQMPRV YFVLLGETMG QVTEKLQLTY MEETCRHYVA HVKRRVQDVI SPIVFEAAYS LSEHVTGEEE RELPPLTPVL RWKKGQKIAQ KNQTVFERNC RSEDCAADLQ LQGKLLLSSM DEKTLYLALG AVKNISLNIS ISNLGDDAYD ANVSFNVSRE LFFINMWQKE EMGISCELLE SDFLKCSVGF PFMRSKSKYE FSVIFDTSHL SGEEEVLSFI VTAQSGNTER SESLHDNTLV LMVPLMHEVD TSITGIMSPT SFVYGESVDA ANFIQLDDLE CHFQPINITL QVYNTGPSTL PGSSVSISFP NRLSSGGAEM FHVQEMVVGQ EKGNCSFQKN PTPCIIPQEQ ENIFHTIFAF FTKSGRKVLD CEKPGISCLT AHCNFSALAK EESRTIDIYM LLNTEILKKD SSSVIQFMSR AKVKVDPALR VVEIAHGNPE EVTVVFEALH NLEPRGYVVG WIIAISLLVG ILIFLLLAVL LWKMGFFRRR YKEIIEAEKN RKENEDSWDW VQKNQ