ITA8_HUMAN » Integrin alpha-8

ITA8_HUMAN » Integrin alpha-8
Magnify ITA8_HUMAN » Integrin alpha-8Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITA8_HUMAN » Integrin alpha-8 »
Hydrophobic Thickness 36.0 ± 4.8 Å
Tilt Angle 35 ± 2°
ΔGtransfer -34.4 kcal/mol
ΔGfold -28.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 1010-1039 (1006-1043)
Pathways

Arrhythmogenic right ventricular cardiomyopathy (KEGG)

Cell adhesion molecules (KEGG)

Dilated cardiomyopathy (KEGG)

ECM-receptor interaction (KEGG)

Extracellular matrix organization (Reactome)

Focal adhesion (KEGG)

Hypertrophic cardiomyopathy (KEGG)

PI3K-Akt signaling pathway (KEGG)

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

ITB1, Complex: ITA8:TENA:ITB1, PubMed

Domains

AA: 321-363, PDBID: 3VI3, Subunit A, Seq Identity:52%, FG-GAP repeat

AA: 386-422, PDBID: 3VI3, Subunit A, Seq Identity:42%, FG-GAP repeat

AA: 483-934, PDBID: 1JV2, Subunit A, Seq Identity:47%, Integrin alpha

AA: 1035-1049, PDBID: 1DPK, Subunit A, Seq Identity:58%, Integrin alpha cytoplasmic region

UniProt annotation for ITA8_HUMAN » Integrin alpha-8
FUNCTION: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.

SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-8 associates with beta-1.

TISSUE SPECIFICITY: Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).

DISEASE: Renal hypodysplasia/aplasia 1 (RHDA1) OMIM: A perinatally lethal renal disease encompassing a spectrum of kidney development defects, including renal agenesis, bilateral renal aplasia, hypoplasia, (cystic) dysplasia, and severe obstructive uropathy. caused by mutations affecting the gene represented in this entry.

UniProt features for ITA8_HUMAN » Integrin alpha-8
SIGNAL 1 38 Potential.
CHAIN 39 1063 Integrin alpha-8.
CHAIN 39 906 Integrin alpha-8 heavy chain (Potential).
CHAIN 907 1063 Integrin alpha-8 light chain (Potential).
REPEAT 44 105 FG-GAP 1.
REPEAT 122 183 FG-GAP 2.
REPEAT 188 240 FG-GAP 3.
REPEAT 253 310 FG-GAP 4.
REPEAT 311 372 FG-GAP 5.
REPEAT 373 431 FG-GAP 6.
REPEAT 435 498 FG-GAP 7.
MOTIF 455 457 Cell attachment site (Potential).
DISULFID 96 106 By similarity.
DISULFID 150 171 By similarity.
DISULFID 187 200 By similarity.
DISULFID 507 518 By similarity.
DISULFID 524 580 By similarity.
DISULFID 641 647 By similarity.
DISULFID 713 726 By similarity.
DISULFID 867 924 Interchain (between heavy and light chains) (By similarity).
DISULFID 929 934 By similarity.
Amino Acid Sequence for ITA8_HUMAN » Integrin alpha-8
MSPGASRGPR GSQAPLIAPL CCAAAALGML LWSPACQAFN LDVEKLTVYS GPKGSYFGYA VDFHIPDART ASVLVGAPKA NTSQPDIVEG GAVYYCPWPA EGSAQCRQIP FDTTNNRKIR VNGTKEPIEF KSNQWFGATV KAHKGKVVAC APLYHWRTLK PTPEKDPVGT CYVAIQNFSA YAEFSPCRNS NADPEGQGYC QAGFSLDFYK NGDLIVGGPG SFYWQGQVIT ASVADIIANY SFKDILRKLA GEKQTEVAPA SYDDSYLGYS VAAGEFTGDS QQELVAGIPR GAQNFGYVSI INSTDMTFIQ NFTGEQMASY FGYTVVVSDV NSDGLDDVLV GAPLFMEREF ESNPREVGQI YLYLQVSSLL FRDPQILTGT ETFGRFGSAM AHLGDLNQDG YNDIAIGVPF AGKDQRGKVL IYNGNKDGLN TKPSQVLQGV WASHAVPSGF GFTLRGDSDI DKNDYPDLIV GAFGTGKVAV YRARPVVTVD AQLLLHPMII NLENKTCQVP DSMTSAACFS LRVCASVTGQ SIANTIVLMA EVQLDSLKQK GAIKRTLFLD NHQAHRVFPL VIKRQKSHQC QDFIVYLRDE TEFRDKLSPI NISLNYSLDE STFKEGLEVK PILNYYRENI VSEQAHILVD CGEDNLCVPD LKLSARPDKH QVIIGDENHL MLIINARNEG EGAYEAELFV MIPEEADYVG IERNNKGFRP LSCEYKMENV TRMVVCDLGN PMVSGTNYSL GLRFAVPRLE KTNMSINFDL QIRSSNKDNP DSNFVSLQIN ITAVAQVEIR GVSHPPQIVL PIHNWEPEEE PHKEEEVGPL VEHIYELHNI GPSTISDTIL EVGWPFSARD EFLLYIFHIQ TLGPLQCQPN PNINPQDIKP AASPEDTPEL SAFLRNSTIP HLVRKRDVHV VEFHRQSPAK ILNCTNIECL QISCAVGRLE GGESAVLKVR SRLWAHTFLQ RKNDPYALAS LVSFEVKKMP YTDQPAKLPE GSIAIKTSVI WATPNVSFSI PLWVIILAIL LGLLVLAILT LALWKCGFFD RARPPQEDMT DREQLTNDKT PEA