ITA6_HUMAN » Integrin alpha-6

ITA6_HUMAN » Integrin alpha-6
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITA6_HUMAN » Integrin alpha-6 » CD49 antigen-like family member F;VLA-6;
Hydrophobic Thickness 38.8 ± 1.2 Å
Tilt Angle 1 ± 1°
ΔGtransfer -60.0 kcal/mol
ΔGfold -29.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 1053-1081 (1053-1084)
Pathways

Arrhythmogenic right ventricular cardiomyopathy (KEGG)

Cell adhesion molecules (KEGG)

Cell-Cell communication (Reactome)

Dilated cardiomyopathy (KEGG)

ECM-receptor interaction (KEGG)

Extracellular matrix organization (Reactome)

Focal adhesion (KEGG)

Hematopoietic cell lineage (KEGG)

Hemostasis (Reactome)

Hypertrophic cardiomyopathy (KEGG)

Pathways in cancer (KEGG)

PI3K-Akt signaling pathway (KEGG)

Regulation of actin cytoskeleton (KEGG)

Signal Transduction (Reactome)

Small cell lung cancer (KEGG)

Toxoplasmosis (KEGG)

PDB none
OPM none
Complexes none
Interactions

A4, Complex: A4:ITA6, PubMed

ADAM9, Complex: ADAM9:ITA6, PubMed

AMPN, Complex: AMPN:ITA6, PubMed

BASI, Complex: ITB1:BASI:ITA6, PubMed

CALX, Complex: CALX:ITA6, PubMed

COHA1, Complex: COHA1:ITA6, PubMed

ITB1, Complex: CD151:ITB1:ITA6, PubMed

ITB4, Complex: ITB4:LAMA5:LAMC1:LAMB1:ITA6, PubMed

PCSK5, Complex: ITA6:PCSK5, PubMed

Domains

AA: 355-393, PDBID: 3VI3, Subunit A, Seq Identity:44%, FG-GAP repeat

AA: 503-978, PDBID: 1JV2, Subunit A, Seq Identity:24%, Integrin alpha

UniProt annotation for ITA6_HUMAN » Integrin alpha-6
FUNCTION: Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.

SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21.

TISSUE SPECIFICITY: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).

DISEASE: Epidermolysis bullosa letalis, with pyloric atresia (EB- PA) OMIM: An autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa. Note=The disease is caused by mutations affecting the gene represented in this entry.

UniProt features for ITA6_HUMAN » Integrin alpha-6
SIGNAL 1 23
CHAIN 24 1130 Integrin alpha-6.
CHAIN 24 938 Integrin alpha-6 heavy chain (Potential).
CHAIN 942 1130 Integrin alpha-6 light chain (Potential).
REPEAT 30 95 FG-GAP 1.
REPEAT 101 166 FG-GAP 2.
REPEAT 176 229 FG-GAP 3.
REPEAT 283 340 FG-GAP 4.
REPEAT 341 402 FG-GAP 5.
REPEAT 403 458 FG-GAP 6.
REPEAT 459 518 FG-GAP 7.
REGION 1077 1083 Interaction with HPS5.
MOTIF 1079 1083 GFFKR motif.
DISULFID 86 94 By similarity.
DISULFID 131 154 By similarity.
DISULFID 175 188 By similarity.
DISULFID 528 535 By similarity.
DISULFID 541 601 By similarity.
DISULFID 665 671 By similarity.
DISULFID 765 776 By similarity.
DISULFID 920 967 Interchain (between heavy and light chains) (By similarity).
DISULFID 973 978 By similarity.
Amino Acid Sequence for ITA6_HUMAN » Integrin alpha-6
MAAAGQLCLL YLSAGLLSRL GAAFNLDTRE DNVIRKYGDP GSLFGFSLAM HWQLQPEDKR LLLVGAPRAE ALPLQRANRT GGLYSCDITA RGPCTRIEFD NDADPTSESK EDQWMGVTVQ SQGPGGKVVT CAHRYEKRQH VNTKQESRDI FGRCYVLSQN LRIEDDMDGG DWSFCDGRLR GHEKFGSCQQ GVAATFTKDF HYIVFGAPGT YNWKGIVRVE QKNNTFFDMN IFEDGPYEVG GETEHDESLV PVPANSYLGL LFLTSVSYTD PDQFVYKTRP PREQPDTFPD VMMNSYLGFS LDSGKGIVSK DEITFVSGAP RANHSGAVVL LKRDMKSAHL LPEHIFDGEG LASSFGYDVA VVDLNKDGWQ DIVIGAPQYF DRDGEVGGAV YVYMNQQGRW NNVKPIRLNG TKDSMFGIAV KNIGDINQDG YPDIAVGAPY DDLGKVFIYH GSANGINTKP TQVLKGISPY FGYSIAGNMD LDRNSYPDVA VGSLSDSVTI FRSRPVINIQ KTITVTPNRI DLRQKTACGA PSGICLQVKS CFEYTANPAG YNPSISIVGT LEAEKERRKS GLSSRVQFRN QGSEPKYTQE LTLKRQKQKV CMEETLWLQD NIRDKLRPIP ITASVEIQEP SSRRRVNSLP EVLPILNSDE PKTAHIDVHF LKEGCGDDNV CNSNLKLEYK FCTREGNQDK FSYLPIQKGV PELVLKDQKD IALEITVTNS PSNPRNPTKD GDDAHEAKLI ATFPDTLTYS AYRELRAFPE KQLSCVANQN GSQADCELGN PFKRNSNVTF YLVLSTTEVT FDTPDLDINL KLETTSNQDN LAPITAKAKV VIELLLSVSG VAKPSQVYFG GTVVGEQAMK SEDEVGSLIE YEFRVINLGK PLTNLGTATL NIQWPKEISN GKWLLYLVKV ESKGLEKVTC EPQKEINSLN LTESHNSRKK REITEKQIDD NRKFSLFAER KYQTLNCSVN VNCVNIRCPL RGLDSKASLI LRSRLWNSTF LEEYSKLNYL DILMRAFIDV TAAAENIRLP NAGTQVRVTV FPSKTVAQYS GVPWWIILVA ILAGILMLAL LVFILWKCGF FKRSRYDDSV PRYHAVRIRK EEREIKDEKY IDNLEKKQWI TKWNRNESYS