ITA5_HUMAN » Integrin alpha-5

ITA5_HUMAN » Integrin alpha-5
Magnify ITA5_HUMAN » Integrin alpha-5Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ITA5_HUMAN » Integrin alpha-5 » Fibronectin receptor subunit alpha;Integrin alpha-F;VLA-5;CD49 antigen-like family member E;
Hydrophobic Thickness 29.6 ± 1.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -49.5 kcal/mol
ΔGfold -26.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 997-1021 (997-1023)
Pathways

Arrhythmogenic right ventricular cardiomyopathy (KEGG)

Bacterial invasion of epithelial cells (KEGG)

Developmental Biology (Reactome)

Dilated cardiomyopathy (KEGG)

ECM-receptor interaction (KEGG)

Extracellular matrix organization (Reactome)

Focal adhesion (KEGG)

Hematopoietic cell lineage (KEGG)

Hemostasis (Reactome)

Hypertrophic cardiomyopathy (KEGG)

Pertussis (KEGG)

Phagosome (KEGG)

PI3K-Akt signaling pathway (KEGG)

Proteoglycans in cancer (KEGG)

Regulation of actin cytoskeleton (KEGG)

Shigellosis (KEGG)

Signal Transduction (Reactome)

PDB 3vi3 (A/C=42-664), 3vi4 (A/C=42-664), 4wjk (A=42-491), 4wk0 (A=42-491), 4wk2 (A=42-491), 4wk4 (A=42-491)
OPM none
Complexes

ITB1:ITA5_HUMAN

Interactions

ACVL1, Complex: ACVL1:ITA5, PubMed

ADA15, Complex: ADA15:ITB1:ITA5, PubMed

AUP1, Complex: AUP1:ITA5, PubMed

EGFR, Complex: ITA5:EGFR, PubMed

EGLN, Complex: EGLN:ITA5, PubMed

ERBB2, Complex: ERBB2:ITA5, PubMed

FGFR2, Complex: ITA5:FGFR2, PubMed

ITB1, Complex: ITA5:ITB1, PDBID: 3vi3, PubMed

ITB3, Complex: ITA5:ITB3:TGM2, PubMed

ITB5, Complex: ITB5:ITA5, PubMed

ITB6, Complex: ITA5:ITB6:TENA, PubMed

L1CAM, Complex: ITA5:L1CAM, PubMed

NRP1, Complex: ITA5:NRP1, PubMed

PECA1, Complex: PECA1:ITA5, PubMed

SE1L1, Complex: SE1L1:ITA5

TGFR1, Complex: TGFR1:ITA5, PubMed

VCAM1, Complex: VCAM1:ITA5

VGFR3, Complex: ITA5:VGFR3, PubMed

Domains

AA: 326-368, PDBID: 3VI3, Subunit A, Seq Identity:100%, FG-GAP repeat

AA: 392-428, PDBID: 3VI3, Subunit A, Seq Identity:100%, FG-GAP repeat

AA: 489-921, PDBID: 3VI3, Subunit A, Seq Identity:100%, Integrin alpha

UniProt annotation for ITA5_HUMAN » Integrin alpha-5
FUNCTION: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi"s sarcoma lesions.

SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV- 1 Tat. Interacts with CIB1.

UniProt features for ITA5_HUMAN » Integrin alpha-5
SIGNAL 1 41
CHAIN 42 1049 Integrin alpha-5.
CHAIN 42 894 Integrin alpha-5 heavy chain.
CHAIN 895 1049 Integrin alpha-5 light chain.
REPEAT 43 108 FG-GAP 1.
REPEAT 128 188 FG-GAP 2.
REPEAT 192 245 FG-GAP 3.
REPEAT 259 315 FG-GAP 4.
REPEAT 316 377 FG-GAP 5.
REPEAT 378 437 FG-GAP 6.
REPEAT 441 504 FG-GAP 7.
REGION 1021 1028 Interaction with HPS5.
MOTIF 1024 1028 GFFKR motif.
DISULFID 99 108
DISULFID 156 176
DISULFID 192 205
DISULFID 513 522
DISULFID 528 584
DISULFID 645 651
DISULFID 718 731
DISULFID 869 921 Interchain (between heavy and light chains).
DISULFID 911 916
Amino Acid Sequence for ITA5_HUMAN » Integrin alpha-5
MGSRTPESPL HAVQLRWGPR RRPPLLPLLL LLLPPPPRVG GFNLDAEAPA VLSGPPGSFF GFSVEFYRPG TDGVSVLVGA PKANTSQPGV LQGGAVYLCP WGASPTQCTP IEFDSKGSRL LESSLSSSEG EEPVEYKSLQ WFGATVRAHG SSILACAPLY SWRTEKEPLS DPVGTCYLST DNFTRILEYA PCRSDFSWAA GQGYCQGGFS AEFTKTGRVV LGGPGSYFWQ GQILSATQEQ IAESYYPEYL INLVQGQLQT RQASSIYDDS YLGYSVAVGE FSGDDTEDFV AGVPKGNLTY GYVTILNGSD IRSLYNFSGE QMASYFGYAV AATDVNGDGL DDLLVGAPLL MDRTPDGRPQ EVGRVYVYLQ HPAGIEPTPT LTLTGHDEFG RFGSSLTPLG DLDQDGYNDV AIGAPFGGET QQGVVFVFPG GPGGLGSKPS QVLQPLWAAS HTPDFFGSAL RGGRDLDGNG YPDLIVGSFG VDKAVVYRGR PIVSASASLT IFPAMFNPEE RSCSLEGNPV ACINLSFCLN ASGKHVADSI GFTVELQLDW QKQKGGVRRA LFLASRQATL TQTLLIQNGA REDCREMKIY LRNESEFRDK LSPIHIALNF SLDPQAPVDS HGLRPALHYQ SKSRIEDKAQ ILLDCGEDNI CVPDLQLEVF GEQNHVYLGD KNALNLTFHA QNVGEGGAYE AELRVTAPPE AEYSGLVRHP GNFSSLSCDY FAVNQSRLLV CDLGNPMKAG ASLWGGLRFT VPHLRDTKKT IQFDFQILSK NLNNSQSDVV SFRLSVEAQA QVTLNGVSKP EAVLFPVSDW HPRDQPQKEE DLGPAVHHVY ELINQGPSSI SQGVLELSCP QALEGQQLLY VTRVTGLNCT TNHPINPKGL ELDPEGSLHH QQKREAPSRS SASSGPQILK CPEAECFRLR CELGPLHQQE SQSLQLHFRV WAKTFLQREH QPFSLQCEAV YKALKMPYRI LPRQLPQKER QVATAVQWTK AEGSYGVPLW IIILAILFGL LLLGLLIYIL YKLGFFKRSL PYGTAMEKAQ LKPPATSDA